Toxicological Effects of Para-Phenylenediamine on kidneys of Female Albino Rats.
mohamed, O., hassan, N., mitwalli, I., hussein, A. (2023). Toxicological Effects of Para-Phenylenediamine on kidneys of Female Albino Rats.. EKB Journal Management System, 1(1), 1-12. doi: 10.21608/bfstj.2021.160432
omima refaat mohamed; nermine adly hassan; islam samy mitwalli; asmaa yaseen hussein. "Toxicological Effects of Para-Phenylenediamine on kidneys of Female Albino Rats.". EKB Journal Management System, 1, 1, 2023, 1-12. doi: 10.21608/bfstj.2021.160432
mohamed, O., hassan, N., mitwalli, I., hussein, A. (2023). 'Toxicological Effects of Para-Phenylenediamine on kidneys of Female Albino Rats.', EKB Journal Management System, 1(1), pp. 1-12. doi: 10.21608/bfstj.2021.160432
mohamed, O., hassan, N., mitwalli, I., hussein, A. Toxicological Effects of Para-Phenylenediamine on kidneys of Female Albino Rats.. EKB Journal Management System, 2023; 1(1): 1-12. doi: 10.21608/bfstj.2021.160432

Toxicological Effects of Para-Phenylenediamine on kidneys of Female Albino Rats.

Biannual Forensic Sciences and Toxicology Journal
Article 1, Volume 1, Issue 1 - Serial Number 202311, 2023, Page 1-12  XML PDF (1.02 MB)
Document Type: Original Article
DOI: 10.21608/bfstj.2021.160432
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Authors
omima refaat mohamed email 1; nermine adly hassan2; islam samy mitwalli3; asmaa yaseen hussein3
1FOENSI MEDICINE AND CLINICAL TOXICOLOGY DEPARTMENT BNHA FACULTY O MEDICINE
2forensic science and clinical toxicology
3forensic medicine and clinical toxicology
Abstract
Background: Para-phenylenediamine (PPD) is a chemical substance used mainly in synthesis of printing ink, photographic solutions, photocopying, temporary tattoos, dark colored cosmetics. Continuous exposure to Para-phenylenediamine has side effect on both kidney structure and function in female albino rats. Aim of work: This study aimed to evaluate the toxicological effects of para-phenylenediamine on the kidneys of female albino rats. Methods: The total experimental period was 60 days, 72female adult albino rats were used as follows: negative control; positive control (distilled water on the shaved skin, H2O2 6% on the shaved skin, distilled water on the hairy skin and H2O2 6% on the hairy skin); test group I: PPD solution in distilled water (10mg / kg /day) on shaved skin & on hairy skin; test group II: PPD dissolved in H2O2 6% (10 mg /kg/ day) on shaved skin& on hairy skin. The study assessed: serum level of creatinine & urea; examination of the renal tissues by Light microscope and Transmission electron microscope. Results: The present study showed increase in level of blood urea &serum creatinine, with degenerative changes in the kidney in all test groups with test group (PPD on shaved skin) most affected. Conclusion: PPD has toxicological effects on the kidney.
Keywords
PPD; H2O2; oxidative stress; kidney
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