The impact of vanadium on endothelial dysfunction in type 2 diabetic rats: Histological insight
Haidara, M., El Karib, A., Bin-Jaliah, I., Morsy, M., Shatoor, A., Bashir, S., El-Gamal, B., Kemeir, M., Eid, R. (2014). The impact of vanadium on endothelial dysfunction in type 2 diabetic rats: Histological insight. EKB Journal Management System, 6(1), 83-91. doi: 10.21608/eajbsc.2014.16049
Mohamed A Haidara; Abbas O. El Karib; Ismaeel Bin-Jaliah; Mohamed D. Morsy; Abdullah S. Shatoor; Salah O. Bashir; Basiouny A . El-Gamal; Mohammed El-Hassan Kemeir; Refaat A. Eid. "The impact of vanadium on endothelial dysfunction in type 2 diabetic rats: Histological insight". EKB Journal Management System, 6, 1, 2014, 83-91. doi: 10.21608/eajbsc.2014.16049
Haidara, M., El Karib, A., Bin-Jaliah, I., Morsy, M., Shatoor, A., Bashir, S., El-Gamal, B., Kemeir, M., Eid, R. (2014). 'The impact of vanadium on endothelial dysfunction in type 2 diabetic rats: Histological insight', EKB Journal Management System, 6(1), pp. 83-91. doi: 10.21608/eajbsc.2014.16049
Haidara, M., El Karib, A., Bin-Jaliah, I., Morsy, M., Shatoor, A., Bashir, S., El-Gamal, B., Kemeir, M., Eid, R. The impact of vanadium on endothelial dysfunction in type 2 diabetic rats: Histological insight. EKB Journal Management System, 2014; 6(1): 83-91. doi: 10.21608/eajbsc.2014.16049

The impact of vanadium on endothelial dysfunction in type 2 diabetic rats: Histological insight

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Article 8, Volume 6, Issue 1, June 2014, Page 83-91  XML PDF (388.06 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2014.16049
View on SCiNiTO View on SCiNiTO
Authors
Mohamed A Haidara1; Abbas O. El Karib2; Ismaeel Bin-Jaliah2; Mohamed D. Morsy2; Abdullah S. Shatoor3; Salah O. Bashir4; Basiouny A . El-Gamal5; Mohammed El-Hassan Kemeir6; Refaat A. Eid7
1Department of Physiology., Electron Microscopy Unit, College of Medicine, King Khalid Univ
2Department of Physiology, Electron Microscopy Unit, College of Medicine, King Khalid Univ
3Depatment of Medicine, Electron Microscopy Unit, College of Medicine, King Khalid Univ
4Depatment of physiology, Electron Microscopy Unit, College of Medicine, King Khalid Univ
5Department of Biochemistry, Electron Microscopy Unit, College of Medicine, King Khalid Univ
6Department of Anatomy, Electron Microscopy Unit, College of Medicine, King Khalid Univ
7Department of Pathology, Electron Microscopy Unit, College of Medicine, King Khalid Univ
Abstract
Introduction: The aim of this research is to investigate the effect of vanadium and or insulin on endothelial dysfunction in type 2 diabetic rats (T2DM). 
Material and methods:60 white albino rats were included in this research and randomly divided into 6 groups(n=10) as follows: Control group (Control): rats injected once intraperitoneally (i.p.)  with citrate buffer  (0.1 M, pH 4.5), vanadium treated group (Vanadium): rats  received vanadyl sulfate of 0.64 mmol/kg weight freshly dissolved in 1 ml of distilled water daily through a nesophageal tube, diabetic type 2group(D type 2)  : rats received high fat diet for 15 days followed by streptozotocin (25 mg/kg body weight ), diabetic type 2 and  insulin  group (D type 2 +I): D type 2 rats received mixtard insulin subcutaneously in a dose of 0.75 IU/100 gm weight in 0.75 ml volume once daily,  diabetic type 2 and  vanadium  group (D type 2+V): type 2 diabetic ratsreceived the same dose of vanadium as in vanadium group after 48 h of induction of type 2 diabetes,  diabetic type 2 + insulin + vanadium group (D type 2 +V+I): diabetic type 2 rats received both vanadium and insulin with the same doses as in previous groups.
Results: Diabetic group showed hyperglycemia, increased cholesterol(C), triglycerides (TG), LDL-C and decrease HDL-C. Administration of both insulin and vanadium caused significant decrease of glucose, TG, C, LDL-C and increased HDL-C back to control level. Histological analysis of aortae documented our results.
Conclusion: Administration of vanadium enhances the effect of insulin and restore endothelial damage in T2DM.
Keywords
Vanadium; endothelial dysfunction; diabetic rats
Statistics
Article View: 190
PDF Download: 230