Does Glucose–Insulin–Potassium Infusion during on-pump Coronary Revascularization Affect Perioperative Inotropic Requirements? | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 52, Volume 83, Issue 1, April 2021, Page 1142-1148 PDF (531.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2021.160888 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Essam Ezzat Abd El-Hakeem; Ahmed Elsaied Abd Elrahman Aly; Osama Salah El Din Mahmoud; Eman Ebraheem Darweesh; Ahmad Hamody Hassan | ||||
| Abstract | ||||
| Background: During coronary artery bypass grafting (CABG), the myocardium is subjected to endure periods of ischemia and reperfusion, which may result in post-ischemic contractile dysfunction. That is a major contributor to early and late morbidity and mortality and increased requirement of pharmacologic and mechanical circulatory support.Glucose insulin potassium (GIK) infusion was thought to provide a cardioprotective effect. Objective: To investigate whether the use of GIK solution in patients undergoing on-pump CABG affects requirements of inotropes. Patients and Method: In this prospective, randomized placebo-controlled trial, 64 patients were assigned into two groups: the GIK group in which glucose-insulin and potassium infusion was given during CABG surgery, and the non-GIK group in which only saline infusion was given during the procedure. Results: In the GIK group, all patient needed not more than two inotropes with mean of 1.28 ± 0.46, while in the non-GIK group there were patients who need up to three inotropes with mean of 1.56 ± 0.56 (P. value of 0.032). Conclusion: GIK infusion during on-pump CABG reduces perioperative inotropic requirements. | ||||
| Keywords | ||||
| CABG; Cardiac Protection; Inotropic support; GIK | ||||
|
Statistics Article View: 155 PDF Download: 309 |
||||
