Protective effect of oregano water extract against Carbon tetrachloride induced Hepatotoxicity in female rats | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 7, Volume 5, Issue 2, December 2013, Page 67-76 PDF (176.52 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2013.16096 | ||||
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| Authors | ||||
| Muhammad E. A. El-Shafeey1; Tarek H. Taha2 | ||||
| 1Department of Medical Biotechnology, Genetic Engineering and Biotechnology Research Institute (GEBRI), City for Scientific Research and Technology Applications (SRTA-City), New Borg El-Arab City, 21934, Alexandria, Egypt. | ||||
| 2-Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute (GEBRI), City for Scientific Research and Technology Applications (SRTA-City), New Borg El-Arab City, 21934, Alexandria, Egypt. | ||||
| Abstract | ||||
| Carbon tetrachloride (CCL4) is one of the most toxic chemicals causes oxidative stress in the living organisms. Our experiment started with twenty female rats that were divided into 4 groups; The 1st groupG1 served as control group, 2nd group G2 injected twice a week with CCL4 diluted in olive oil (1:1 v/v), 3rd group G3 were fed daily for 14 days with 1ml of Oregano water extract and the 4th group G4 were injected with CCL4 plus daily feeding with 1ml of Oregano water extract. The biochemical results indicated a significant elevation in the liver and kidney functions including ALT, AST, creatinine, uric acid and urea for the 2nd group due to the toxicity induced by the CCL4. The levels of ALT, AST, creatinine, urea and uric acid were significantly decreased after the administration of oregano water extract in the 4th group. Lipid profile was evaluated in the four groups by measuring the levels of total cholesterol, HDL-C and triglycerides. The variation noticed by the over and down expression of the liver genes due to CCl4 was explored. These up and down regulated genes were tracked using differential display technique. | ||||
| Keywords | ||||
| Oregano water extract; Carbon tetrachloride; Hepatotoxicity; Rats | ||||
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