Synthesis and antibacterial evaluation of some new pyrimidine, pyridine and thiophene derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Article 46, Volume 64, Issue 7, July 2021, Page 3691-3701 PDF (804.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.65453.3404 | ||||
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| Authors | ||||
Ahmed El-Shareef; Abdelhaleem Hussein; Abubaker Eladasy; Ismail Othman; Ahmed Khames  
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| Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt. | ||||
| Abstract | ||||
| New series of pyrimidine, pyridine and thiophene derivatives were prepared by reaction of appropriate 3-oxobutanamides with urea, thiourea, active methylene compounds, arylidines, salicyaldehyde, chalcones, benzoylisothiocyanate and aminopyrazoles. The antimicrobial activities were also studied and have been found that; Compounds 2a, 3a, 3c and 9 show activity against some bacterial species, whereas, no activity was observed for compounds 3b, 4, 5, 7e, 7f, 10 and 11 against all bacterial species | ||||
| Keywords | ||||
| p-Aminobenzoic acid; 3-oxobutanamides; pyrimidines; pyridines; thiophenes and antimicrobial activity | ||||
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