A Study of the Effect of the Use of Antioxidants in Patients with Hepatitis C Receiving Interferon/Ribavirin Therapy on the Response to Therapy
Hegazy, I., Elbadrawy, E., Khorshid, S., Elnemr, S., Fathy, T., Metwally, A., Ismael, M., Gouda, A. (2012). A Study of the Effect of the Use of Antioxidants in Patients with Hepatitis C Receiving Interferon/Ribavirin Therapy on the Response to Therapy. EKB Journal Management System, 2(4), 168-177. doi: 10.21608/aeji.2012.16185
Ibrahim M Hegazy; Elsaid G Elbadrawy; Soha Khorshid; Sahar Elnemr; Talaat Fathy; Ashraf Metwally; Magdy Ismael; Amal A Gouda. "A Study of the Effect of the Use of Antioxidants in Patients with Hepatitis C Receiving Interferon/Ribavirin Therapy on the Response to Therapy". EKB Journal Management System, 2, 4, 2012, 168-177. doi: 10.21608/aeji.2012.16185
Hegazy, I., Elbadrawy, E., Khorshid, S., Elnemr, S., Fathy, T., Metwally, A., Ismael, M., Gouda, A. (2012). 'A Study of the Effect of the Use of Antioxidants in Patients with Hepatitis C Receiving Interferon/Ribavirin Therapy on the Response to Therapy', EKB Journal Management System, 2(4), pp. 168-177. doi: 10.21608/aeji.2012.16185
Hegazy, I., Elbadrawy, E., Khorshid, S., Elnemr, S., Fathy, T., Metwally, A., Ismael, M., Gouda, A. A Study of the Effect of the Use of Antioxidants in Patients with Hepatitis C Receiving Interferon/Ribavirin Therapy on the Response to Therapy. EKB Journal Management System, 2012; 2(4): 168-177. doi: 10.21608/aeji.2012.16185

A Study of the Effect of the Use of Antioxidants in Patients with Hepatitis C Receiving Interferon/Ribavirin Therapy on the Response to Therapy

Afro-Egyptian Journal of Infectious and Endemic Diseases
Article 6, Volume 2, Issue 4, December 2012, Page 168-177  XML PDF (412.92 K)
Document Type: Original Article
DOI: 10.21608/aeji.2012.16185
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Authors
Ibrahim M Hegazy1; Elsaid G Elbadrawy1; Soha Khorshid1; Sahar Elnemr1; Talaat Fathy1; Ashraf Metwally1; Magdy Ismael2; Amal A Gouda email 1
1Tropical Medicine Department, Faculty of Medicine,Zagazig University, Egypt.
2Pathology Department, Faculty of Medicine,Zagazig University, Egypt
Abstract
Background and study aim: Treatment of HCV with interferon takes a long duration and has many side effects. The use of antioxidants with interferon/ribavirin therapy is believed to minimize the side effects and improves adherence and hence improves response to therapy. Reactive oxygen species are part of the human defense mechanisms towards infection and they increase due to hepatitis C virus infection. In this study we aim to study the impact of the concomitant use of antioxidants with interferon/ribavirin combination therapy for HCV on response as regards enzymes level, rate of viral clearance as well as liver histopathology.. Patients and methods: 240 patients on interferon/ribavirin therapy for chronic hepatitis C divided in two groups. The test group received concomitant antioxidant combination while the control group received only interferon/ribavirin. Follow up of liver function tests, complete blood count, viral load by PCR and post treatment histopathology by liver biopsy were performed. Results: Liver enzymes level in test group achieved a larger and faster decline than in control group. Hematological parameters were significantly higher in the test group all through period of follow up. Viral load and histopathology showed no significant difference between the two groups. Conclusion: concomitant use of antioxidants with interferon/ ribavirin therapy minimizes complications of therapy and rapidly normalizes the liver enzymes level without affecting the rate of response to therapy or histopathology of the liver.
Keywords
antioxidants; hepatitis C
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