VINCULIN GENE EXPRESSION IN A COHORT OF EGYPTIAN PATIENTS WITH HEART FAILURE INDUCED BY ACUTE CORONARY SYNDROME | ||||
| ALEXMED ePosters | ||||
| Article 97, Volume 3, Issue 2, June 2021, Page 28-29 | ||||
| Document Type: Preliminary preprint short reports of original research | ||||
| DOI: 10.21608/alexpo.2021.70926.1144 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Noha Mohamed Noureldin Abdelfattah 
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| Department of Clinical and Chemical Pathology, Faculty of Medicine University of Alexandria. | ||||
| Abstract | ||||
| Heart failure (HF) remains a rising global epidemic with an estimated prevalence of >37.7 million individuals globally. Coronary artery disease is the most common form of heart disease and the most common cause of heart failure. Studying gene expression profile in heart failure could serve as a convenient tool contributing to identifying diagnostic and prognostic markers as well as targets for therapeutic intervention It was suggested that vinculin (VCL), a member of the family of membrane-associated proteins, may affect cardiac repair in heart failure. Vinculin is a force-sensitive protein, regulates cell shape and intracellular signaling. During cardiac stress and failure, there are significant alterations in the expression of cardiomyocyte cytoskeletal proteins, including vinculin. Studies addressing the role of VCL in remodeling after cardiac injury are limited. However, in this study we present an evidence that VCL may be a key player during hypertrophic and ischemic cardiac remodeling. Aim of the work The aim of the work was to evaluate Vinculin gene and protein expression in heart failure induced by Acute Coronary Syndrome (ACS). | ||||
| Keywords | ||||
| Heart failure (HF); vinculin (VCL); Acute Coronary Syndrome (ACS) | ||||
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