Effect of Grape Seed Extract on Oxidative Damages in Gamma Irradiated Rats | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 8, Volume 48, Issue 1, July 2012, Page 414-428 PDF (341.56 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2012.16245 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Abdelgawad.A. Fahmi1; M.A. El- Desouky1; Neama M. El-Fatih2; Wissam.A. Mohamed1 | ||||
| 1Chemistry Department, Faculty of Science, Cairo university | ||||
| 2Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Cairo, Egypt | ||||
| Abstract | ||||
| Back ground: Ionizing radiation is known to produce deleterious effects in the living organisms. Aim of the work: The aim of this study is to evaluate the possible protective effect of the chemical constituents of grape seed extract on oxidative stress induced by gamma rays. Materials & Methods: Rats were subjected to 8 Gy fractionated doses of gamma radiation, grape seed extract 100 mg/kg body weights were daily administrated before and within radiation exposure.All parameters were investigated at 1st and 14th days post last radiation exposure. Results: The results revealed that administration of grape seed extract to irradiated rats significantly ameliorates the changes induced in antioxidant system. TBARS (lipid peroxidation index) were significantly decreased when compared with their equivalent values in irradiated rats. In conclusion, the administration of grape seed extract to irradiated rats might provide substantial protection against oxidative damages due to its free radical scavenging and antioxidant properties of its ingredients. It could be suggested that, grape seed extract may have a potential benefits to people receiving radiotherapy. | ||||
| Keywords | ||||
| Grape seed extract; γ-irradiation; Oxidative Stress; mitochondria; and Antioxidant Enzymes | ||||
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