COMPARATIVE STUDY BETWEEN INTRAVITREAL VERSUS SUBTENON INJECTION OF TRIAMCINOLONE ACETONIDE IN MANAGEMENT OF DIABETIC MACULAR OEDEMA | ||||
| Egyptian Journal of Clinical Ophthalmology | ||||
| Article 3, Volume 2, Issue 2, December 2019, Page 57-68 PDF (1.38 MB) | ||||
| Document Type: Original articles: include clinical trials, interventional research, Basic researches and clinically relevant laboratory investigations | ||||
| DOI: 10.21608/ejco.2019.162985 | ||||
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| Authors | ||||
| Abd El-Rahman, M.; Abd El-badie, M.; Mohamed, A. | ||||
| Ophthalmology dept., Faculty of Medicine, Al-Azhar Univ., Assiut, Egypt | ||||
| Abstract | ||||
| Purpose: To study the difference in the both safety and efficacy of Intravitreal (IVTA)versus subtenon (STTA ) triamcinolone acetonide injection as a treatment approach of diabetic macular edema (DME). Patients and Methods: 50 eyes of 38 diabetic patients diagnosed DME according to the ETDRS criteria were divided into two groups; each group consists of twenty five eyes. Group A were injected IVTA with 4 mg (0.1ml). Group B were injected STTA with 40 mg (1ml). Results: In group Awe found that the mean central macular thickness (CMT) reduced from 465.6 u ± 170.8 u at the baseline level to 285.9 u ± 83.2 u,267.5 u ± 79 u and 288.4u ±169.8uat 1,3 and 6 months post injection respectively. In group B we found that the mean CMT reduced from 327.65u ± 68.4 u at the baseline level to 273.2 u ± 77.9, 257.8u ± 83.6u and 264.9u ±104.3uat 1.3 and 6 months post injection respectively. In group A we found that the mean visual acuity (VA) was improved from 0.2 at the baseline to 0.4, 0.3 and 0.4 at 1, 3 and 6 months post injection respectively. In group B we found that the mean VA was improved from 0.3 at the baseline to 0.5, 0.7 and 0.7at 1.3 and 6 months post injection respectively. In group A we found that the mean intra ocular pressure (IOP)was changed from 16.2 mmHg ±1.2 mmHg at the baseline to20.9 mmHg ±6.9 mmHg, 17.4 mmHg ±1.6 mm Hg and 17.4 mmHg ±1.6 mmHg at 1,3 and 6 months post injection respectively. In group B we found that the mean IOP was changed from15.15mmHg ±1.8 mmHg at the baseline to15.6 mmHg ±1.8 mmHg, 15.8mmHg ±1.8 mmHg and15.7 mmHg ±1.8mmHg at 1.3 and 6 months post injection respectively. Conclusion: STTA can achieve clinical results comparable to IVTA as regards the reduction of CMT and the improvement of VA although it achieves this effect somewhat slower. | ||||
| Keywords | ||||
| Diabetic macular edema; Intra vitreal triamcinolone acetonide injection; Subtenon triamcinolone acetonide injection | ||||
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