The role of CD58 and CD38 in evaluation of minimal residual disease in childhood B-acute lymphoblastic leukemia | ||||
| Zagazig University Medical Journal | ||||
| Article 22, Volume 28, Issue 3, May 2022, Page 558-566 PDF (399.46 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2021.65960.2162 | ||||
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| Authors | ||||
Eman Abdel Aziz  1; Mervat Azab2; Ahmed Mohamed Baraka3; Tamer Hasan Hassan4; Maha Atfy5; Ahmed Mokhtar Ahmed2
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| 1clinical pathology department, faculty of medicine, Zagazig university | ||||
| 2clinical pathology department, faculty of medicine, Zagazig university , Egypt | ||||
| 3Department of clinical pathology , faculty of medicine , Zagazig University | ||||
| 4pediatrics department, faculty of medicine, Zagazig university , Egypt | ||||
| 5clinical pathology department, faculty of medicine, Zagazig University | ||||
| Abstract | ||||
| Background: Measurement of minimal residual disease (MRD) reflects the overall response to therapy, and could be used to refine the treatment of acute lymphoblastic leukemia (ALL). MRD studies by flowcytometry rely on panels of antibodies (Abs) to define unique immunophenotypic signature of leukemic blasts. Aim: to evaluate the role of CD38 and CD58 in detection of MRD in childhood B-ALL. Results: The mean age in our patients was 6.7 years. They were 54% males and 46% females. At day 14 post induction, 25% of our patients were negative for MRD, while 75% were positive for MRD. CD38 under-expression was +ve in 66.7%, while CD58 overexpression was +ve in 50% of the patients at diagnosis. There was a significant increase in +ve CD38 under-expression among patients had +ve MRD. Also there was a significant increase in +ve CD58 overexpression among patients had -ve MRD. CD38 underexpression demonstrated than CD58 overexpression. Conclusion: CD38 is a hopeful marker that needs to be used routinely for assessment of MRD. It is more informative than CD58 in B-ALL patients. CD38 under-expression has higher frequency and less modulation than CD58 overexpression during remission induction therapy. | ||||
| Keywords | ||||
| Minimal residual disease; acute lymphoblastic leukemia; flowcytometry; CD38; CD58 | ||||
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