The Fecal M2-PK As A Novel Biomarker for Screening of Cancer Colon | ||||
| The Egyptian Journal of Community Medicine | ||||
| Article 9, Volume 36, Issue 3, July 2018, Page 93-102 PDF (348.66 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejcm.2018.16337 | ||||
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| Abstract | ||||
| Background: Cancer colon is one of most common cancers worldwide. Colonoscopy; an invasive and costly investigation method is the most reliable tool for diagnosis. Early diagnosis of cancer colon gives a high chance of cure. Fecal M2-PK; a tumor biomarker is a new approach for cancer colon screening. Objective: This study aimed to evaluate fecal M2-PK as a biomarker for cancer colon screening. Methods: This comparative crosssectional study included 3 groups: 30 healthy individuals (Group Ι), 50 diagnosed cancer colon patients (Group П) and 20 cancer colon patients who were the only operable patient from Group П (Group III). For all groups, history and physical examination was done. Fecal M2-PK concentrations were detected by ELISA. Results: The study revealed that there was a significant difference between cancer colon patients and healthy individuals (control) regarding age (p=0.046*), BMI (p=0.004*), history of smoking (p=0.025*), history of low fiber and high protein diet (p=0.001*), and levels of M2-PK (p=0.001*). There was a significant difference in the mean value of M2PK levels in relation to sex (p=0.043*) and site of cancer colon (p=0.002*) only. Cancer colon can be detected with fecal M2-PK with remarkable sensitivity &specificity (98% and 93% respectively). The overall accuracy of M2PK in detecting cancer colon was 96.6%. Conclusion: Fecal M2- PK is considered as a good screening biomarker for cancer colon. | ||||
| Keywords | ||||
| Cancer Colon; M2-PK; biomarker | ||||
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