Spectrophotometric determination of ranitidine hydrochloride and famotidine using 1,2- naphthoquinone-4-sulphonate.
Elsadek, M., Baraka, M., Abdel-Aziz, L., El-Bermawi, S. (2013). Spectrophotometric determination of ranitidine hydrochloride and famotidine using 1,2- naphthoquinone-4-sulphonate.. EKB Journal Management System, 22(2), 8-17. doi: 10.21608/zjps.2013.163438
Mohamed Elsadek; Mohamed Baraka; Lobna Abdel-Aziz; Samar El-Bermawi. "Spectrophotometric determination of ranitidine hydrochloride and famotidine using 1,2- naphthoquinone-4-sulphonate.". EKB Journal Management System, 22, 2, 2013, 8-17. doi: 10.21608/zjps.2013.163438
Elsadek, M., Baraka, M., Abdel-Aziz, L., El-Bermawi, S. (2013). 'Spectrophotometric determination of ranitidine hydrochloride and famotidine using 1,2- naphthoquinone-4-sulphonate.', EKB Journal Management System, 22(2), pp. 8-17. doi: 10.21608/zjps.2013.163438
Elsadek, M., Baraka, M., Abdel-Aziz, L., El-Bermawi, S. Spectrophotometric determination of ranitidine hydrochloride and famotidine using 1,2- naphthoquinone-4-sulphonate.. EKB Journal Management System, 2013; 22(2): 8-17. doi: 10.21608/zjps.2013.163438

Spectrophotometric determination of ranitidine hydrochloride and famotidine using 1,2- naphthoquinone-4-sulphonate.

Zagazig Journal of Pharmaceutical Sciences
Article 2, Volume 22, Issue 2, December 2013, Page 8-17  XML PDF (2.21 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2013.163438
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Authors
Mohamed Elsadek email 1; Mohamed Baraka1; Lobna Abdel-Aziz2; Samar El-Bermawi1
1Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt
Abstract
Accurate, simple and sensitive spectrophotometric method was developed for the determination of ranitidine hydrochloride and famotidine in bulk and pharmaceutical dosage forms. The method was based on the reaction of these drugs with 1,2-naphthoquinone-4sulphonate in alkaline medium, producing colored products measured atʎmax  488nm and 468 nm for ranitidine HCI and famotidine, respectively . Beer’s law was obeyed in the concentration range from (24-120 µg ml -1) for ranitidine HCI and (6-20 µg ml -1) for famotidine with molar absorpitivity 1.498 x 103 Lmol-1 cm -1and 1.441 x 104Lmol-1 cm-1 respectively. The proposed method was successfully applied for the determination of ranitidine HCI and famotidine in their dosage forms with good accuracy and precisions.
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