APPLICATION OF BENESI-HILDEBRAND ALGORITHM IN THE INVESTIGATION OF (1:2) )DRUG:REAGENT) INTERACTIONS OF PHOSPHOMOLYBDIC ACID
Elazazy, M., Hassan, W. (2012). APPLICATION OF BENESI-HILDEBRAND ALGORITHM IN THE INVESTIGATION OF (1:2) )DRUG:REAGENT) INTERACTIONS OF PHOSPHOMOLYBDIC ACID. EKB Journal Management System, 21(1), 20-24. doi: 10.21608/zjps.2012.163458
Marwa Elazazy; Wafaa Hassan. "APPLICATION OF BENESI-HILDEBRAND ALGORITHM IN THE INVESTIGATION OF (1:2) )DRUG:REAGENT) INTERACTIONS OF PHOSPHOMOLYBDIC ACID". EKB Journal Management System, 21, 1, 2012, 20-24. doi: 10.21608/zjps.2012.163458
Elazazy, M., Hassan, W. (2012). 'APPLICATION OF BENESI-HILDEBRAND ALGORITHM IN THE INVESTIGATION OF (1:2) )DRUG:REAGENT) INTERACTIONS OF PHOSPHOMOLYBDIC ACID', EKB Journal Management System, 21(1), pp. 20-24. doi: 10.21608/zjps.2012.163458
Elazazy, M., Hassan, W. APPLICATION OF BENESI-HILDEBRAND ALGORITHM IN THE INVESTIGATION OF (1:2) )DRUG:REAGENT) INTERACTIONS OF PHOSPHOMOLYBDIC ACID. EKB Journal Management System, 2012; 21(1): 20-24. doi: 10.21608/zjps.2012.163458

APPLICATION OF BENESI-HILDEBRAND ALGORITHM IN THE INVESTIGATION OF (1:2) )DRUG:REAGENT) INTERACTIONS OF PHOSPHOMOLYBDIC ACID

Zagazig Journal of Pharmaceutical Sciences
Article 3, Volume 21, Issue 1, June 2012, Page 20-24  XML PDF (1.25 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2012.163458
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Authors
Marwa Elazazy email ; Wafaa Hassan
Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt
Abstract
The reactions between Phosphomolybdic acid (PMA) and Etamsylate (ETM) to form molybdenum blue (Mo5+) (Method A) and Fluconazole (FL) to form an ion associate (Method B) were investigated in terms of stoichiometry both mathematically and chemically. Mathematical characterization of the formed adducts was done using the algorithm proposed by Benesi –Hildebrand (B-H) and sis modifications Values of both the formation constant K (Lmol-1), and molar extinction coefficient £( Lmo1-cm-1 ) were determined using modified B-H'' Rose-Drago'' equation. A molar ratio of (1:2) (Drug: Reagent) was detected applying the mole ratio method applying both methods. Further investigations using B-H equation for (1:1 molar ratio) or'' Rose-Drago '' (for other molar ratios) confirmed the results obtained using the mole ratio method. The obtained values for £AD and K were 1.86 x 106 L.mol.cm-1 and 26.1x1011 L.mol-1 (Method A) and 3. 6 x 103 and 9.36 x 106 (Method B) respectively.
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