Effect of noise stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats.
Helal, E., Eid, F., Taha, N. (2011). Effect of noise stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats.. EKB Journal Management System, 44(1), 295-310. doi: 10.21608/ejhm.2011.16409
Eman G.E. Helal; Fatma Eid; Neama M Taha. "Effect of noise stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats.". EKB Journal Management System, 44, 1, 2011, 295-310. doi: 10.21608/ejhm.2011.16409
Helal, E., Eid, F., Taha, N. (2011). 'Effect of noise stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats.', EKB Journal Management System, 44(1), pp. 295-310. doi: 10.21608/ejhm.2011.16409
Helal, E., Eid, F., Taha, N. Effect of noise stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats.. EKB Journal Management System, 2011; 44(1): 295-310. doi: 10.21608/ejhm.2011.16409

Effect of noise stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats.

The Egyptian Journal of Hospital Medicine
Article 4, Volume 44, Issue 1, July 2011, Page 295-310  XML PDF (1.36 MB)
Document Type: Original Article
DOI: 10.21608/ejhm.2011.16409
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Authors
Eman G.E. Helal1; Fatma Eid2; Neama M Taha3
1Zoology Department ,Faculty of Science,Al-Azhar University ( Physiology)
2Zoology Department ,Faculty of Science,Al-Azhar University. ( Histology)
3Zoology Department ,Faculty of Science,Al-Azhar University
Abstract
Background: Noise is the most stressful factor and human being. So these studies aim to clarify its effect on some physiological and histological parameters.  
 
Material and methods: 24 Female rats were divided into four groups (6/each):1-control, 2-treated with sulpiride drug,3- noise exposure (90db/3h per day for 30days), 4-noise + drug
 
Results: drug recorded a significant  increase only in the percentage of   body weight gain but the other parameters  showed no significant changes. Noise stress recorded a significant increase in glucose, ALT, GGT, TP, globulin.
A significant decrease in percentage of body weight gain and A/G ratio were also detected . It has been detected that Sulpiride drug ameliorated most of these parameters.
 Concerning the histological and histochemical studies sulpiride treatment showed no detectable changes in the liver tissues with exception of increased lymphocytes. Exposure to noise showed many dystrophic change in tissue, but drug treatment improved all the  previous changes and this indicates the protective effect of sulpiride against noise  exposure.      
 
Conclusion: it is useful to use sulpiride drug in people who expose to noise stress.
 
 
Keywords
Noise; Sulpiride drug; albino rats; physiological parameters; Histopathalogy and histochemistery
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