Management of locally advanced periampullary tumor: Multicenter study
Elshikh, E., Yassein, T., Ayoub, E., Ebeed, A., Hossam Elashtokhy, H., Abdelgawad, W., Elsabrout, M., El-lity, M., Youssef, T., Ibrahim, M. (2021). Management of locally advanced periampullary tumor: Multicenter study. EKB Journal Management System, 5(2), 67-79. doi: 10.21608/jcbr.2021.45222.1075
Essam Elshikh; Taha Yassein; Eslam Ayoub; Ahmed Ebeed; Hossam Elashtokhy Hossam Elashtokhy; Walla Abdelgawad; Mohamed Elsabrout; Mosad El-lity; Tarek Youssef; Mohamed Ibrahim. "Management of locally advanced periampullary tumor: Multicenter study". EKB Journal Management System, 5, 2, 2021, 67-79. doi: 10.21608/jcbr.2021.45222.1075
Elshikh, E., Yassein, T., Ayoub, E., Ebeed, A., Hossam Elashtokhy, H., Abdelgawad, W., Elsabrout, M., El-lity, M., Youssef, T., Ibrahim, M. (2021). 'Management of locally advanced periampullary tumor: Multicenter study', EKB Journal Management System, 5(2), pp. 67-79. doi: 10.21608/jcbr.2021.45222.1075
Elshikh, E., Yassein, T., Ayoub, E., Ebeed, A., Hossam Elashtokhy, H., Abdelgawad, W., Elsabrout, M., El-lity, M., Youssef, T., Ibrahim, M. Management of locally advanced periampullary tumor: Multicenter study. EKB Journal Management System, 2021; 5(2): 67-79. doi: 10.21608/jcbr.2021.45222.1075

Management of locally advanced periampullary tumor: Multicenter study

Egyptian Journal of Cancer and Biomedical Research
Article 7, Volume 5, Issue 2, June 2021, Page 67-79  XML PDF (2.96 MB)
Document Type: Original Article
DOI: 10.21608/jcbr.2021.45222.1075
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Authors
Essam Elshikh email orcid 1; Taha Yassein2; Eslam Ayoub3; Ahmed Ebeed4; Hossam Elashtokhy Hossam Elashtokhy5; Walla Abdelgawad6; Mohamed Elsabrout1; Mosad El-lity7; Tarek Youssef1; Mohamed Ibrahimorcid 8
1Surgical Oncology Department, Tanta Cancer Center, Tanta, Egypt
2Surgery Department, NLI, Menufia university, Menufia, Egypt
3Surgery Department, NLI, Menufia University, Menufia, Egypt
4Radiodiagnosis Department, Tanta Cancer Center, Tanta, Egypt
5Medical Oncology Department, Tanta Cancer Center, Tanta, Egypt
6Pathology Department, Faculty of Medicine, Suez University, Suez, Egypt.
7Pathology Department, Tanta Cancer Center, Tanta, Egypt
8General Surgery Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt
Abstract
Background: Pancreas may develop either benign or malignant tumors. Pancreatic cancer (PC) is one of the most lethal solid tumors which ranking as the fourth cause of cancer-related death in the United States. Aim:  To analyze the results of treatment of locally advanced pancreatic cancer to come up with management strategy. Patients and Methods: Patients (n=136) were retrospectively evaluated with periampullary carcinoma where 40 patients were diagnosed as locally advanced periampullary carcinoma, from January 2010 to January 2018 in multicenter. Results: Patients diagnosed as pancreatic head carcinoma in 20/40 and periampullary carcinoma in 20/40 of patients, all patients were diagnosed as locally advanced pancreatic cancer by radiological imaging, where 28/40 (70%) was males and 12/40 (30%) were females with male:female ratio of 2.3:1. The age of patients at diagnosis was 39-62 years with a median age of 51 years. All patientswere = evaluated and followed up for 24 months with Multislice CT, PET-CT and tumor markers. Some patients underwent neoadjuvant treatment for down staging and were then surgery was done for 25/40 cases. Whipple’s operation without VR in 17/25 and VR done in 8/25 cases, where 6/40 cases died during chemotherapy and 9/40 unfit for surgery due to disseminated disease and complications of chemotherapy. Conclusion: Pancreatic cancer patients diagnosed as locally advanced or metastatic tumor need MDT to decide different modes of treatment in order to obtain better results
Keywords
chemotherapy; locally advanced pancreatic carcinoma; pancreatic carcinoma; vascular resection
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