Chemical studies of some fused heterocyclic compounds containing oxygen with anticipated biological interests: Thesis Abstract
El-Sawi, A., Abozeid, M., El-Desoky, E., Abdelrahman, A. (2021). Chemical studies of some fused heterocyclic compounds containing oxygen with anticipated biological interests: Thesis Abstract. EKB Journal Management System, 5(0), 46-46. doi: 10.21608/jcbr.2021.59452.1141
Aya Atef El-Sawi; Mohamed Abozeid; El-Sayed Ibrahim El-Desoky; Abdelrahman Hassun Abdelrahman. "Chemical studies of some fused heterocyclic compounds containing oxygen with anticipated biological interests: Thesis Abstract". EKB Journal Management System, 5, 0, 2021, 46-46. doi: 10.21608/jcbr.2021.59452.1141
El-Sawi, A., Abozeid, M., El-Desoky, E., Abdelrahman, A. (2021). 'Chemical studies of some fused heterocyclic compounds containing oxygen with anticipated biological interests: Thesis Abstract', EKB Journal Management System, 5(0), pp. 46-46. doi: 10.21608/jcbr.2021.59452.1141
El-Sawi, A., Abozeid, M., El-Desoky, E., Abdelrahman, A. Chemical studies of some fused heterocyclic compounds containing oxygen with anticipated biological interests: Thesis Abstract. EKB Journal Management System, 2021; 5(0): 46-46. doi: 10.21608/jcbr.2021.59452.1141

Chemical studies of some fused heterocyclic compounds containing oxygen with anticipated biological interests: Thesis Abstract

Egyptian Journal of Cancer and Biomedical Research
Article 48, Volume 5, Issue 0, May 2021, Page 46-46  XML PDF (174.12 K)
Document Type: Essay Abstract
DOI: 10.21608/jcbr.2021.59452.1141
View on SCiNiTO View on SCiNiTO
Authors
Aya Atef El-Sawi email orcid 1; Mohamed Abozeidorcid 2; El-Sayed Ibrahim El-Desokyorcid 3; Abdelrahman Hassun Abdelrahman3
1Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt
2Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
3Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
Abstract
Thesis Abstract
Background: Heterocyclic are known to have multiple applications in particular biomedical settings. Aim: The present study reports a convenient protocol for the design and synthesis of new heterocyclic compounds incorporating 1- hydroxy-naphthyl and new angular chromones bearing allylnaphthyl fragments. Materials and Methods: The versatile precursor 2-acetyl-4- allyl-1-hydroxy naphthalene was subjected to Claisen-Schmidt condensation but the precursor 6-allyl-3-formyl-4H-benzo[h]chromone was prepared via Vilsmeier–Haack reaction of 4-allyl-1- hydroxy-2-acetonaphthone.
Results: Some new compounds are considered as promising leads with dual biological activity as antibacterial and antioxidant. The isoalloxazine ring of the cofactor FAD is essential to the recognition of the compound that has proper antioxidant activity. Benzocoumarin ring is essential for the recognition of the amino acid residues. Allyl chain improves the p stacking interaction while the n-propyl chain attenuates the overall interaction. Naphthyl ring needs to be substituted with a short bridge to avid the ring extended away from the pocket. The antimicrobial and antiquorum-sensing activities of the newly synthesized compounds showed that many compounds have good and promising activities in comparison with the reference drugs. Conclusion: Based on the computational prediction of pharmacokinetics, drug-likeness properties, biological activity, and molecular docking suggested that formyl chromone and tetracarbonyl may be potent antimicrobial drugs
Keywords
antituberculosis; DFT studies; naphthoxocine
Statistics
Article View: 366
PDF Download: 179