Analysis of the cellular expression of checkpoint molecules on immune cells in patients with breast cancer: Thesis Abstract
Esmail, M., Salem, M., El-Naggar, S., Saad, M., Abd- Elaziz, S. (2021). Analysis of the cellular expression of checkpoint molecules on immune cells in patients with breast cancer: Thesis Abstract. EKB Journal Management System, 5(0), 16-16. doi: 10.21608/jcbr.2021.61808.1168
Mohamed Esmail; Mohamed L Salem; Sabry Ali El-Naggar; Mohamed attia Saad; Sameh Abd- Elaziz. "Analysis of the cellular expression of checkpoint molecules on immune cells in patients with breast cancer: Thesis Abstract". EKB Journal Management System, 5, 0, 2021, 16-16. doi: 10.21608/jcbr.2021.61808.1168
Esmail, M., Salem, M., El-Naggar, S., Saad, M., Abd- Elaziz, S. (2021). 'Analysis of the cellular expression of checkpoint molecules on immune cells in patients with breast cancer: Thesis Abstract', EKB Journal Management System, 5(0), pp. 16-16. doi: 10.21608/jcbr.2021.61808.1168
Esmail, M., Salem, M., El-Naggar, S., Saad, M., Abd- Elaziz, S. Analysis of the cellular expression of checkpoint molecules on immune cells in patients with breast cancer: Thesis Abstract. EKB Journal Management System, 2021; 5(0): 16-16. doi: 10.21608/jcbr.2021.61808.1168

Analysis of the cellular expression of checkpoint molecules on immune cells in patients with breast cancer: Thesis Abstract

Egyptian Journal of Cancer and Biomedical Research
Article 18, Volume 5, Issue 0, May 2021, Page 16-16  XML PDF (182.38 K)
Document Type: Essay Abstract
DOI: 10.21608/jcbr.2021.61808.1168
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Authors
Mohamed Esmail email 1; Mohamed L Salem1; Sabry Ali El-Naggarorcid 2; Mohamed attia Saad3; Sameh Abd- Elaziz4
1Zoology Department, Faculty of Science, Tanta University, Egypt
2Zoology Department, Faculty of Science, Tanta University, Tanta 3111, Egypt
3Clinical Pathology, Faculty of Medicine , Tanta University , Tanta , Egypt.
4Department of Oncology, Oncology Center, Faculty of Medicine, Mansoura University, Egypt
Abstract
Thesis Abstract
Despite of the success of the breast cancer therapies, recurrence and metastasis still occurs after treatment. These may be due to the immune cells suppression through immunoregulatory T cells (T reg) and immune checkpoint pathways such as programmed cell death protein 1 ( PD-1) or programmed cell death ligand 1 (PDL-1) that expressed on circulatory tumor cells (CTCs). The present study aimed to analyze the phenotypic and the functions of immune T cells in the peripheral blood (PB) of breast cancer patients. Further to analyze the expression of checkpoint molecules (PD-1, PDL-1) on immune cells, also analyze the expression of PDL-1 on CTCs and cancer stem cells in (PB) of breast cancer patients, and correlated the results with clinical status of the patients compared to healthy woman. Blood samples were collected from breast cancer patients (n=28) at different stages (II, III, IV) before surgery compared to healthy individuals (n=10) to explore the significant role of T regulatory (Treg) cells, and the expression of PD-1 on immune T cells in (PB) of breast cancer patients. The study showed the significant role of PDL-1 on circulatory tumor cells (CTCs) in peripheral blood of stages (III- IV) of breast cancer patients before and post chemotherapy. Our findings help us to understand the immunomodulatory nature of Treg, PD-1 expression on immune cells and PDL-1 expression on cancer cells. Therefore, provide a better understanding of the nature of a recurrence and metastasis of breast cancer patients, furthermore recommended breast cancer patients needs seriously to immunotherapy.
Keywords
Breast cancer; Circulatory tumor cells; Programmed cell death protein 1; programmed cell death ligand 1; T regulatory cells
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