Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract
Serag Eldeen, H., Al-Zahaby, A., Salem, M. (2021). Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract. EKB Journal Management System, 5(1.1), 17-17. doi: 10.21608/jcbr.2021.61950.1172
Haitham M. Serag Eldeen; Al-Ahmady S. Al-Zahaby; Mohamed Labib Salem. "Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract". EKB Journal Management System, 5, 1.1, 2021, 17-17. doi: 10.21608/jcbr.2021.61950.1172
Serag Eldeen, H., Al-Zahaby, A., Salem, M. (2021). 'Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract', EKB Journal Management System, 5(1.1), pp. 17-17. doi: 10.21608/jcbr.2021.61950.1172
Serag Eldeen, H., Al-Zahaby, A., Salem, M. Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract. EKB Journal Management System, 2021; 5(1.1): 17-17. doi: 10.21608/jcbr.2021.61950.1172

Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract

Egyptian Journal of Cancer and Biomedical Research
Article 19, Volume 5, Issue 1.1, May 2021, Page 17-17  XML PDF (180.26 K)
Document Type: Essay Abstract
DOI: 10.21608/jcbr.2021.61950.1172
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Authors
Haitham M. Serag Eldeen email 1; Al-Ahmady S. Al-Zahaby2; Mohamed Labib Salem3
1Basic Science, Faculty of Physical Therapy, Pharos University in Alexandria
2Zoology Department, Faculty of Science, Zagazig University,Alsharkya, Egypt
3Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt
Abstract
Thesis Abstract
Background: Using of experimental animal as models to mimic human pathological conditions has facilitated ]understanding the mechanisms of different processes involved in these diseases. Among the experimental animals, mice are the mostly widely used animals in different experimental biology since it has a small size, easy breading, low cost, high fertility rate, and the extensive knowledge of its genome.  The differences in the immune cell compmenents between young and adult mice, however, have not been well investigated. Aim: The present study aimed to compare aging  on the immune cell components in outbreed and inbreed mice as well as to evaluate the their responses to the inflammatory stimuli Polyinosinic:polycytidylic acid (poly(I:C)). Results: The study investigated whether the aging or the poly(I:C) has the more damaging effect on the cell histology of the thymus gland and spleen. This study confirms that the  alteration in the histology of the spleen of aged mice as compared to young mice. Furthermore, poly(I:C) had more tendency to induce alteration in teh archetecture and cellular components in the thymus and spleen of old mice than those in young mice. Conclusion: Immune compartments in old mice are more susciptable to inflammation than those in young mice.
Keywords
Aging; Poly I:C; Spleen; Thymus gland
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