Cytokine gene polymorphisms in lymphoma: Thesis Abstract
El-maadawy, E., Talaat, R., Abd El-Aziz, A., Abd El Bary, N. (2021). Cytokine gene polymorphisms in lymphoma: Thesis Abstract. EKB Journal Management System, 5(0), 12-12. doi: 10.21608/jcbr.2021.60776.1159
Eman El-maadawy; roba Talaat; Amal Abd El-Aziz; naser Abd El Bary. "Cytokine gene polymorphisms in lymphoma: Thesis Abstract". EKB Journal Management System, 5, 0, 2021, 12-12. doi: 10.21608/jcbr.2021.60776.1159
El-maadawy, E., Talaat, R., Abd El-Aziz, A., Abd El Bary, N. (2021). 'Cytokine gene polymorphisms in lymphoma: Thesis Abstract', EKB Journal Management System, 5(0), pp. 12-12. doi: 10.21608/jcbr.2021.60776.1159
El-maadawy, E., Talaat, R., Abd El-Aziz, A., Abd El Bary, N. Cytokine gene polymorphisms in lymphoma: Thesis Abstract. EKB Journal Management System, 2021; 5(0): 12-12. doi: 10.21608/jcbr.2021.60776.1159

Cytokine gene polymorphisms in lymphoma: Thesis Abstract

Egyptian Journal of Cancer and Biomedical Research
Article 14, Volume 5, Issue 0, May 2021, Page 12-12  XML PDF (181.95 K)
Document Type: Essay Abstract
DOI: 10.21608/jcbr.2021.60776.1159
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Authors
Eman El-maadawy email 1; roba Talaat2; Amal Abd El-Aziz3; naser Abd El Bary4
1Molecular biology department, genetic engineering and biotechnology research institute, university of sadat city
2Molecular Biology department,Genetic Engineering and Biotechnology Research Institute (GEBRI) University of Sadat City
3Molecular Biology Department Head of Genetic Engineering and Biotechnology Research Institute (GEBRI) university of Sadat City, Egypt
4Clinical oncology department, Faculty of Medicine, Menoufia University, Egypt
Abstract
Thesis Abstract
Several cytokines are known to be involved in the pathogenesis of non-Hodgkin Lymphomas (NHL). Given the importance of understanding the genetic predisposition involved in the pathogenesis of NHL, this work was designed to study the impact of IL-10 (-1082 G/A; rs1800896 and -819 C/T; rs1800871), IL-6 (-174 G/C; rs1800795) and CD38 (184C/G; rs6449182) gene polymorphisms on the susceptibility of Egyptians to NHL. Both loci of IL10 were genotyped using polymerase chain reaction- sequence-specific primers (PCR-SSP), IL6 rs1800795 G/C was genotyped using mutagenically separated PCR (MS-PCR) and restriction fragment length polymorphism-PCR (RFLP-PCR) was used to genotype CD38 (rs6449182 C/G) in 100 Egyptian patients and 119 controls. Plasma levels of IL-6 and IL-10 were measured using enzyme-linked immunosorbent assay (ELISA). An insignificant change in IL-10 (rs1800896 and rs1800871) genotypes were recorded. GT haplotype was significantly elevated.
Keywords
CD38; IL-10; IL-6; NHL; SNP
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