Role of Metformin in Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients: Thesis Abstract
El-fatatry, B., Ibrahim, O., Zakaria, F., Mostafa, T. (2021). Role of Metformin in Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients: Thesis Abstract. EKB Journal Management System, 5(0), 29-29. doi: 10.21608/jcbr.2021.57231.1112
Basma El-fatatry; Osama Ibrahim; Fatma Zakaria; Tarek Mostafa. "Role of Metformin in Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients: Thesis Abstract". EKB Journal Management System, 5, 0, 2021, 29-29. doi: 10.21608/jcbr.2021.57231.1112
El-fatatry, B., Ibrahim, O., Zakaria, F., Mostafa, T. (2021). 'Role of Metformin in Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients: Thesis Abstract', EKB Journal Management System, 5(0), pp. 29-29. doi: 10.21608/jcbr.2021.57231.1112
El-fatatry, B., Ibrahim, O., Zakaria, F., Mostafa, T. Role of Metformin in Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients: Thesis Abstract. EKB Journal Management System, 2021; 5(0): 29-29. doi: 10.21608/jcbr.2021.57231.1112

Role of Metformin in Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients: Thesis Abstract

Egyptian Journal of Cancer and Biomedical Research
Article 31, Volume 5, Issue 0, May 2021, Page 29-29  XML PDF (190.58 K)
Document Type: Essay Abstract
DOI: 10.21608/jcbr.2021.57231.1112
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Authors
Basma El-fatatry email orcid 1; Osama Ibrahim2; Fatma Zakaria3; Tarek Mostafa4
1Clinical Phaarmacy Department, Faculty of Pharmacy, Tanta University
2Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
3Oncology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
4Cllinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Abstract
Thesis Abstract

Background: Metformin, an anti-diabetic drug, has been found in recent studies to have multifactorial efffects in different clinical settings. Aim: Peripheral sensory neuropathy is the most prominently reported adverse effect of oxaliplatin. This study was conducted to evaluate metformin role in oxaliplatin-induced neuropathy. Patients and Methods: From November 2014 to May 2016, 40 patients with stage III colorectal cancer were enrolled and randomly allocated to a control group, received 12 cycles of FOLFOX-4 regimen, and a metformin group, received the same regimen plus metformin 500 mg three times daily. The metformin efficacy was evaluated using the brief pain inventory short form “worst pain” item, National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE version 4.0) and a12-item neurotoxicity questionnaire (Ntx-12) from the validated Functional Assessment of Cancer Therapy/Gynecologic Oncology Group. In addition to malondialdehyde, interleukin-6 and neurotensin serum levels assessment. Results: At the end of the 12th cycle, the mean pain score in metformin group was significantly lower than those of control group, (6.7 versus 7.3, P = 0.005). On the other hand, 95% of patients in control group experienced grade 2 and 3 neuropathy while only 60% experienced grade 2 and 3 neuropathy. Furthermore, metformin group showed significantly higher total scores of Ntx-12 questionnaire than control group (24.0 versus 19.2, P < 0.001). Mean serum levels of malondialdehyde and neurotensin were significantly lower in metformin group after the 6th and the 12th cycles. Conclusion: Metformin may be a promising drug in protecting colorectal cancer patients against oxaliplatin-induced chronic peripheral sensory neuropathy
Keywords
Colorectal cancer; Metformin; Peripheral neuropathy; Oxaliplatin
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