In Vitro Survival of Breast Cancer Cell Lines Following Chemotherapy or Radiotherapy in Comparison with Gold-mediated Phototherapy: Thesis Abstract
Moussa, S., Shalaby, T., Zaher, E., Elnaggar, M., Nakhla, S. (2021). In Vitro Survival of Breast Cancer Cell Lines Following Chemotherapy or Radiotherapy in Comparison with Gold-mediated Phototherapy: Thesis Abstract. EKB Journal Management System, 5(0), 23-23. doi: 10.21608/jcbr.2021.60568.1150
S Moussa; Thanaa Shalaby; E Zaher; M Elnaggar; Sameh Nakhla. "In Vitro Survival of Breast Cancer Cell Lines Following Chemotherapy or Radiotherapy in Comparison with Gold-mediated Phototherapy: Thesis Abstract". EKB Journal Management System, 5, 0, 2021, 23-23. doi: 10.21608/jcbr.2021.60568.1150
Moussa, S., Shalaby, T., Zaher, E., Elnaggar, M., Nakhla, S. (2021). 'In Vitro Survival of Breast Cancer Cell Lines Following Chemotherapy or Radiotherapy in Comparison with Gold-mediated Phototherapy: Thesis Abstract', EKB Journal Management System, 5(0), pp. 23-23. doi: 10.21608/jcbr.2021.60568.1150
Moussa, S., Shalaby, T., Zaher, E., Elnaggar, M., Nakhla, S. In Vitro Survival of Breast Cancer Cell Lines Following Chemotherapy or Radiotherapy in Comparison with Gold-mediated Phototherapy: Thesis Abstract. EKB Journal Management System, 2021; 5(0): 23-23. doi: 10.21608/jcbr.2021.60568.1150

In Vitro Survival of Breast Cancer Cell Lines Following Chemotherapy or Radiotherapy in Comparison with Gold-mediated Phototherapy: Thesis Abstract

Egyptian Journal of Cancer and Biomedical Research
Article 25, Volume 5, Issue 0, May 2021, Page 23-23  XML PDF (191.43 K)
Document Type: Essay Abstract
DOI: 10.21608/jcbr.2021.60568.1150
View on SCiNiTO View on SCiNiTO
Authors
S Moussa1; Thanaa Shalaby2; E Zaher1; M Elnaggar3; Sameh Nakhla email orcid 1
1Department of Radiation Sciences, Medical Research Institute, Alexandria University, Alexandria, Egypt
2Department of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, Egypt
3Department of Cancer Management and Research,Medical Research Institute, Alexandria University, Alexandria, Egypt
Abstract
Thesis Abstract
Background: Breast cancer is a heterogeneous disease that mandate efficient therapeutics, lower drug toxicity, and overcoming drug resistance. Combination therapy was suggested as a future treatment to attain the required efficacy and tolerable side effects. Aim: The current study aimed to compare and evaluate the efficacy of single and combined treatments in the MCF-7 breast cancer cell line. Materials and Methods: The study included seven MCF-7 groups according to the treatment modality. Cell viability was evaluated by MTT assay at different doses and time course treatments. Results: When nanoparticles were used alone, the starting point of significant cell death was 100 µg, but when using a photothermal combination modality the loss of viability % was bout 2- fold higher than nanoparticles alone especially in low concentrations and there was a significant difference between the 2 groups. There was a significant difference in cell viability between FAC + AuNPs group when compared to FAC only or control group (p ≤ 0.05). There was a significant difference in cell viability between Taxol + AuNPs when compared to control (p ≤ 0.05). there is a significant effect of radiation doses on cell viability within all subgroups ( p < 0.001 for R0, and p=0.001 for R2 subgroup). there is a significant effect of the radiation doses on the cell viability within each subgroup as indicated by significant p values ( p= 0.027 for RN0, and p=0.001 for RN2). Conclusion: Combined GNPs and FAC, paclitaxel, and Radiotherapy treatment modalities could improve breast cancer outcomes and prognosis.
Keywords
Breast cancer; Chemotherapy; MCF-7; Photothermal treatment; Radiosensitizers
Statistics
Article View: 296
PDF Download: 229