Immunohistochemical Study of a Correlation between Pemphigus Vulgaris Activity Score and Stem Cell Control | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 66, Volume 83, Issue 1, April 2021, Page 1224-1229 PDF (725.41 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2021.165168 | ||||
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| Authors | ||||
| Heba A. S. Bazid1; Iman Seleit1; Samar Saeed Shaban Abo Hegazy* 2; Rehab Monir Samaka3 | ||||
| 1Departments of 1Dermatology, Andrology & STDs Faculty of Medicine, Menoufia University, Egypt | ||||
| 2Departments of 1Dermatology, Andrology & STDs Faculty of Medicine, Menoufia University, Egypt | ||||
| 3Departments of STDs and Pathology, Faculty of Medicine, Menoufia University, Egypt | ||||
| Abstract | ||||
| Background: Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease. PV autoantibodies disrupt desmosomal adhesion and cause acantholysis. Previous researches have shown that stem cells are indirectly involved as a result of desmoglein deficiency. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) as a follicular stem cell marker was evaluated in aim to correlate its intensity of expression with disease severity. Objective: To correlate LGR5 intensity of expression with disease severity. Patient and methods: This prospective cross sectional study was carried out on 20 PV patients. Patients were subjected to complete history taking, general, dermatological examination and assessment of disease severity by the Pemphigus Vulgaris Activity Score (PVAS), histopathological and immunohistochemical expression of LGR5 were done. Results: All studied cases showed positive cytoplasmic basal LGR5 expression in patchy manner. 75% of cases had mild intensity of expression, 15% had moderate intensity and their Histo (H) score ranged from 50-130 with Mean ±SD 110±18.92. There were no significant correlation between PVAS scores ''skin, mucosa and total involvement'' and H score of LGR5 expression. Conclusion: The current study could shed a new light on the disease and its correlation with stem cells, LGR5 as a stem cell marker could be related to the healing process in PV. However, it didn't correlate PVAS scores either in skin, mucosa or total involvement. | ||||
| Keywords | ||||
| LGR5; Pemphigus vulgaris; Stem cells; Skin; Autoimmune | ||||
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