Antimicrobial and Cytotoxicity Evaluation of New 3-Allyl-2-iminothiazolidin-4-ones | ||||
| Egyptian Journal of Chemistry | ||||
| Article 23, Volume 64, Issue 9, September 2021, Page 4919-4930 PDF (1.71 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.68822.3517 | ||||
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| Authors | ||||
Shaymaa G. Hammad1; Marwa G. El-Gazzar 1; Mohammad Abdel-Halim 2; Eman Z. Elrazaz 3; Ebaa M. El-Hossary  1; Khaled A.M. Abouzid 4
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| 1Drug Radiation Research Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Ahmed El-Zomor St. 3, El-Zohoor Dist., Nasr City, 11765 Cairo, Egypt | ||||
| 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt | ||||
| 3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain-Shams University, Abbassia, 11566 Cairo, Egypt | ||||
| 4Professor of pharmaceutical chemistry Dean of the Faculty of Pharmacy, University of Sadat City Sadat City, Menoufia, Egypt | ||||
| Abstract | ||||
| A series of novel 3-allyl-2-iminothiazolidin-4-one derivatives (4-17) was synthesized, through the reaction of 3-allyl-2-((3,4-dichlorophenyl)imino)thiazolidin-4-one (3) with different aromatic aldehydes. The chemical stability of four representative thiazolidinone derivatives (3, 11, 13 and 14) was evaluated against γ-irradiation, at a radiation dose of 25 kGy. The compounds were found to be stable with no observed degradation in liquid chromatography–mass spectrometry (LC-MS) experiments. The synthesized thiazolidinone derivatives (3-17) were evaluated for their antimicrobial and anticancer activities. Among the tested compounds, compounds 5, 7, 8, 14 and 16 exhibited slight antibacterial activity against a multi-drug resistant Staphylococcus aureus (ATCC 43300 strain), at a concentration of 32 µg/mL. Compound 3 fully inhibited the growth of the fungal pathogen Cryptococcus neoformans, at a tested concentration of 32 µg/mL. Besides, compound 12 inhibited the biofilm formation of S. aureus (HG001 strain), with a percentage of 54% at a concentration of 64 µg/mL. Compared to the other tested compounds, compound 11 showed higher in vitro anticancer activity against melanoma and breast cancer cells, with growth inhibition values ranging from 42% to 73% at a concentration of 10 µM. Interestingly, only compounds 3, 8 and 16 showed weak cytotoxicity to murine fibroblast L929 cells, at a tested concentration of 100 µM. The other tested compounds were not cytotoxic to fibroblasts, which suggests the relative safety of the synthesized compounds to normal mammalian cells. | ||||
| Keywords | ||||
| 1,3-Thiazolidin-4-one; Chemical stability; Antibacterial; Antifungal; Antibiofilm; Anticancer | ||||
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