ASSESSMENT OF EFFICACY OF NITAZOXANIDE VERSUS GARLIC IN TREATMENT OF CRYPTOSPORIDIOSIS AMONG HIV INFECTED PATIENTS IN FEVER HOSPITAL, ALEXANDRIA | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 2, Volume 51, Issue 1, April 2021, Page 9-16 PDF (1.01 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2021.165928 | ||||
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| Authors | ||||
| Heba Said Ibrahim; MOSTAFA ABU EL HODA MOHAMED; HALA ALI SHEHATA; ESRAA ALI FARAHAT | ||||
| Department of Parasitology, Medical Research Institute, Alexandria University, Alexandria, Egypt | ||||
| Abstract | ||||
| Cryptosporidium is one of major causes of diarrhea in Human immunodeficiency virus (HIV) positive patients. Due to increasing problems of inadequate and unreliable medical treatments for Cryptosporidium enteritis among HIV patients, alternative therapies were being studied. garlic has widely been used to treat intestinal parasites. The treatment with garlic evoked a significant reduction in the worm load. The present study aimed to evaluate the performance of traditional medical plant (garlic) as compared to Nitazoxanide in the treatment of cryptosporidiosis among HIV infected patients. Subjects and methods: Stool samples were collected from (150 HIV) positive patients and examined microscopically using Formalin ethyl acetate and Modified Ziehl Neelsen (MZN) stain. Also, Cryptosporidium coproantigen was detected using Enzyme linked immunosorbent assay (ELISA) technique. All positive cases were divided into 2 groups, the first group was treated with NTZ 500 mg, twice daily for 6 days and the second group was treated by garlic 300 mg twice daily for the same period. Stool samples were collected one week after treatment and were examined using MZN and ELISA technique. The results showed that Cryptosporidium infection was 15.3% by using MZN &10.7% by using ELISA (total positive cases were 26), without significant difference between cryptosporidiosis and demographic factors (age, sex, residence). By comparing treatment of Cryptosporidium infection, the cure rate was 100% by garlic compared to 58.3% by NTZ. All cases cured by garlic whether CD4 T cell count was above or below 350 , but one case with CD4 T cells was not cured by NTZ. | ||||
| Keywords | ||||
| Cryptosporidium; HIV; patients; Nitazoxanide; Garlic | ||||
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