ASSESSMENT OF THE EFFECT OF ALLIUM SATIVUM (GARLIC) AND CURCUMA LONGA (CURCUMIN) IN COMBINATION WITH DRUGS O N CULTURED TRICHOMONAS VAGINALIS | ||||
Journal of the Egyptian Society of Parasitology | ||||
Article 4, Volume 51, Issue 1, April 2021, Page 23-28 PDF (923.1 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jesp.2021.165934 | ||||
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Authors | ||||
ahmed kamal dyab 1; HANY A. FAROUK2; MOHAMMED F. MOHAMMED3; YASSER M. MOHAMED4 | ||||
1Department of Medical Parasitology, Faculty of Medicine, Assiut University, Egypt | ||||
2Department of Gynecology and Obstetrics,Aswan University, Egypt | ||||
3Department of Medical Parasitology, Faculty of Medicine Aswan University, Egypt | ||||
4Department of Medical Parasitology, Faculty of Medicine, Assiut University, 71515 Assiut, Egypt | ||||
Abstract | ||||
Trichomoniasis is an infectious disease caused by Trichomonas vaginalis. It inflicts severe complications to human genitourinary system. The devastating negative effects and resistance emerged to known medication impose the search for effective and safer alternatives. This study evaluated the effect of curcumin and garlic as well as combination between their effective doses with Metronidazole® & Tinidazole®. So, vaginal swabs were obtained from the symptomatic patients, and cultured on modified Diamond's medium. Assessment of the herbs various concentrations at different follow-up periods was done by counting dead T. vaginalis trophozoites by using hemocytometer and trypan blue staining. The results showed that curcumin 400mg/ml gave a promising anti-Trichomonas especially when combined with garlic 90mg/ml that showed a high synergistic effect. | ||||
Keywords | ||||
Curcumin; Garlic; Trichomonas vaginalis; Culture; Metronidazole; Tinidazole | ||||
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