EFFICACY OF PENTAVALENT ANTIMONIAL INJECTION IN IMPROVING THE OXIDATIVE, NITROSATIVE STATUS AND IMMUNE CELLULAR ENZYME ACTIVITY IN TREATING SAUDI PATIENTS WITH CUTANEOUS LEISHMANIASIS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 13, Volume 51, Issue 1, April 2021, Page 99-106 PDF (694.37 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2021.165947 | ||||
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| Authors | ||||
| HAMDAN I. ALMOHAMMED1; MOSSAD A. SAIF2; AISHAH E. ALBALAWI3; ABDULLAH D. ALANAZI4 | ||||
| 1Department of Microbiology and Parasitology, Almaarefa University, Riyadh 11597 | ||||
| 2Department of Parasitology, Faculty of Medicine, King Faisal University P.O. Box 400, AlAhsa19822 | ||||
| 3Faculty of Science, University of Tabuk, Tabuk 47912 | ||||
| 4Department of Biological Science, Faculty of Science and Humanities, Shaqra University, Ad-Dawadimi 11911 | ||||
| Abstract | ||||
| Macrophages, within which Leishmania sp. replicate, generate large amounts of reactive oxygen species and reactive nitrogen species to kill these parasites. The present study aimed to assess the oxidative and nitrosative stresses and activities of key immune response enzymes in the serum of patients with cutaneous leishmaniasis (CL) before and after treatment with sodium stibogluconate as well as in the control individuals. Serum activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and levels of reduced glutathione, malondialdehyde (MDA), and nitric oxide (NO) as well as those of L-arginase, myeloperoxidase (MPO), and adenosine deaminase (ADA) were studied. The activities of Larginase, MPO, ADA, and MDA and levels of NO were significantly elevated (P < 0.001), whereas those of SOD, CAT, and GSH-Px and levels of GSH were significantly reduced (P < 0.001) before treatment compared with those after treatment and in control individuals. Treatment ameliorated these agents in comparison with the untreated group, but there were still variations between the values of the treated and control groups. Thus, oxidative and nitrosative stresses may play an essential role in the pathogenesis of untreated CL. | ||||
| Keywords | ||||
| Cutaneous leishmaniasis; Antioxidants; Nitric oxide; Adenosine deaminase; Myeloperoxidase; Lipid peroxidation | ||||
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