Synthesis And Antitumor Potential Of New 7-Halocoumarin-4-Acetic Acid Derivatives
Mustafa, Y., Khalil, R., Mohammed, E. (2021). Synthesis And Antitumor Potential Of New 7-Halocoumarin-4-Acetic Acid Derivatives. EKB Journal Management System, 64(7), 3711-3716. doi: 10.21608/ejchem.2021.68873.3508
Yasser Mustafa; Raghad Riyadh Khalil; Eman Tareq Mohammed. "Synthesis And Antitumor Potential Of New 7-Halocoumarin-4-Acetic Acid Derivatives". EKB Journal Management System, 64, 7, 2021, 3711-3716. doi: 10.21608/ejchem.2021.68873.3508
Mustafa, Y., Khalil, R., Mohammed, E. (2021). 'Synthesis And Antitumor Potential Of New 7-Halocoumarin-4-Acetic Acid Derivatives', EKB Journal Management System, 64(7), pp. 3711-3716. doi: 10.21608/ejchem.2021.68873.3508
Mustafa, Y., Khalil, R., Mohammed, E. Synthesis And Antitumor Potential Of New 7-Halocoumarin-4-Acetic Acid Derivatives. EKB Journal Management System, 2021; 64(7): 3711-3716. doi: 10.21608/ejchem.2021.68873.3508

Synthesis And Antitumor Potential Of New 7-Halocoumarin-4-Acetic Acid Derivatives

Egyptian Journal of Chemistry
Article 48, Volume 64, Issue 7, July 2021, Page 3711-3716  XML PDF (463.56 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.68873.3508
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Authors
Yasser Mustafa email orcid 1; Raghad Riyadh Khalilorcid 2; Eman Tareq Mohammedorcid 2
1Pharmaceutical Chemistry Department, College of Pharmacy, Mosul University-41002, Nineveh, Iraq.
2Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul-41001, Iraq
Abstract
Compounds having their chemical structure based on coumarin framework have enticed much research concern not only because of the variance structural characteristic but also the pluralism of the bioactivities. In this report, four derivatives of 7-halo-4-coumarinylacetic acid referred to as RY1-RY4 were synthesized, and their chemical backbones were confirmed via the employed spectrophotometers. The pharmacokinetic profiles of the synthesized halocoumarins were inspected in silico using a free online software named the pre-ADMET program. The potential of the synthesized halocoumarins as antitumor applicants was evaluated utilizing 5-fluorouracil as a reference drug and the well-authenticated protocol based on the MTT as a visible indicator against eight standard tumor-cell lines. The outcomes acquired from this assessment indicated that the synthesized halocoumarins, except RY1, have less impact as antitumor agents comparing with the standard drug. Also, the halocoumarins revealed roughly the same fashion of activity versus the test cell lines with the greatest inhibitory influence reported against MCF-7 and HeLa. From the calculated pharmacokinetic data and outcomes exhibited from antitumor assessment, the authors concluded that the synthesized halocoumarins, particularly RY1, offered potential applicants as antitumor agents with broad-ranged activity. Besides, the compounds RY1 and RY2 may provide highly valuable scaffolds for synthesizing agents with a powerful antitumor activity versus the breast and cervical cancer phenotypes.
Keywords
Halocoumarins; Synthesis; Antitumor; MTT assay; Pharmacokinetic parameters
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