Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity
Alfarouk, O., Barakat, A., Shoman, S., Ghanem, H., Ali, M., Rashad, A. (2013). Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity. EKB Journal Management System, 5(1), 25-33. doi: 10.21608/eajbsg.2013.16642
Omar R. Alfarouk; Ahmed B. Barakat; Sahar A. Shoman; Husam A. Ghanem; Mohamed A. Ali; Aymn E. Rashad. "Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity". EKB Journal Management System, 5, 1, 2013, 25-33. doi: 10.21608/eajbsg.2013.16642
Alfarouk, O., Barakat, A., Shoman, S., Ghanem, H., Ali, M., Rashad, A. (2013). 'Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity', EKB Journal Management System, 5(1), pp. 25-33. doi: 10.21608/eajbsg.2013.16642
Alfarouk, O., Barakat, A., Shoman, S., Ghanem, H., Ali, M., Rashad, A. Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity. EKB Journal Management System, 2013; 5(1): 25-33. doi: 10.21608/eajbsg.2013.16642

Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity

Egyptian Academic Journal of Biological Sciences, G. Microbiology
Article 4, Volume 5, Issue 1, June 2013, Page 25-33  XML PDF (256.54 K)
Document Type: Original Article
DOI: 10.21608/eajbsg.2013.16642
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Authors
Omar R. Alfarouk1; Ahmed B. Barakat1; Sahar A. Shoman2; Husam A. Ghanem2; Mohamed A. Ali3; Aymn E. Rashad4
1- Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt
2Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt
3Department of water pollution, National Research Center, Dokki, Cairo, Egypt
4Department of Photochemistry, National Research Center, Dokki,Cairo, Egypt
Abstract
Thirteen chemical compounds belonging to the fused heterocyclic pyrimidines were synthesized and screened in order to assay their antiviral activity against the avian influenza virus (H5N1) A/Chicken/Qalubiya/1/2006(H5N1) by plaque reduction assay on MDCK cells. All tested compounds were non-toxic on the cells. Ten out of thirteen compounds (10, 13, 9, 12, 1, 11, 7, 8, 3 and 4) showed moderate percentage of inhibition respectively at concentration 20 μg/ml while the remaining three compounds (5, 2 and 6) showed weak inhibitory activity respectively at same concentration.
Keywords
Anti; Avian influenza virus; H5N1 – pyrimidine derivatives
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