Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives
Elgiushy, H., Hammad, S., Hassan, A., Aboutaleb, N., Abouzid, K. (2018). Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives. EKB Journal Management System, 2(4), 221-237. doi: 10.21608/aprh.2018.2839.1049
Hossam Elgiushy; Sherif Hammad; Ashraf Sayed Hassan; Nageh Aboutaleb; khaled Abouzid. "Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives". EKB Journal Management System, 2, 4, 2018, 221-237. doi: 10.21608/aprh.2018.2839.1049
Elgiushy, H., Hammad, S., Hassan, A., Aboutaleb, N., Abouzid, K. (2018). 'Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives', EKB Journal Management System, 2(4), pp. 221-237. doi: 10.21608/aprh.2018.2839.1049
Elgiushy, H., Hammad, S., Hassan, A., Aboutaleb, N., Abouzid, K. Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives. EKB Journal Management System, 2018; 2(4): 221-237. doi: 10.21608/aprh.2018.2839.1049

Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives

Journal of Advanced Pharmacy Research
Article 1, Volume 2, Issue 4, October 2018, Page 221-237  XML PDF (999.75 K)
Document Type: Review Article
DOI: 10.21608/aprh.2018.2839.1049
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Authors
Hossam Elgiushy email 1; Sherif Hammad1; Ashraf Sayed Hassanorcid 2; Nageh Aboutaleb1; khaled Abouzid3
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan 11795, Cairo, Egypt.
2Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt
3Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University,Abbassia 11566 Cairo , Egypt
Abstract
Acrylamide moiety is a pronounced Michael acceptor that has drawn much interest in a wide array of drugs designed for various therapeutic purposes. Herein we outline different synthetic pathways, scientific bases for its chemical reactivity and how it is functionalized for design of new therapeutic entities, in addition to a brief insight into spectrum of reported biological activities of acrylamide containing compounds up to date.
Keywords
acrylamide; antitumor; Covalent inhibitors; Kinase inhibitors, Michael acceptor
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