Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes
El-Boraey, H., Serag El-Din, A., EL-Gammal, O. (2021). Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes. EKB Journal Management System, 64(9), 5153-5166. doi: 10.21608/ejchem.2021.69667.3539
Hanaa A. El-Boraey; Azza A. Serag El-Din; Ohyla A. EL-Gammal. "Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes". EKB Journal Management System, 64, 9, 2021, 5153-5166. doi: 10.21608/ejchem.2021.69667.3539
El-Boraey, H., Serag El-Din, A., EL-Gammal, O. (2021). 'Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes', EKB Journal Management System, 64(9), pp. 5153-5166. doi: 10.21608/ejchem.2021.69667.3539
El-Boraey, H., Serag El-Din, A., EL-Gammal, O. Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes. EKB Journal Management System, 2021; 64(9): 5153-5166. doi: 10.21608/ejchem.2021.69667.3539

Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes

Egyptian Journal of Chemistry
Article 47, Volume 64, Issue 9, September 2021, Page 5153-5166  XML PDF (880.11 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.69667.3539
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Authors
Hanaa A. El-Boraey1; Azza A. Serag El-Din2; Ohyla A. EL-Gammal email 3
1Department of Chemistry, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt
2Department of Chemistry, The Regional Institute Joint of Medical and Chemical Analysis, Ministry of Health, Shebin El-Kom, Egypt
3Department of Pathology, University Hospital, Menoufia University, Shebin El- Kom, Egypt
Abstract
In the present study, new Co(II), Ni(II) and Cu(II) complexes were synthesized from the reaction of tetradentate Schiff’s base ligand (H2L)= (N, N'-(pyridine- 2,6- diyl) bis (2- (((Z)- (2- hydroxynaphthalen-1-yl) methylene) amino) benzamide that was synthesized via condensation of 2-amino-N-{2-[(2-amino-benzoylamino) pyridine]-benzamide} with 2-hydroxy-1-naphthaldehyde. The ligand and its metal (II) complexes were characterized by microanalyses, magnetic, spectral, powder X-ray diffraction (XRD) and thermal studies. An octahedral geometry has been proposed for [Co(L)(H2O)2].3H2O (1), [Ni(L)(H2O)2].1½H2O (2) and square planar for [Cu(L)](3) and [Cu(H2L)(OH)Br](4). EPR spectra of Cu(II) complexes are consistent with d x²-y² ground state. 3D molecular modeling studies have been carried out for ligand and complex (1). Average crystallite size (D) and dislocation density (δ) were calculated from XRD. All compounds were screened for their in vitro antioxidant activity. The results showed that the ligand possesses excellent activity compared to the reference (Ascorbic acid drug) and complex (4) was the most potent one. Moreover, the current compounds were tested for their antimicrobial activity.
Keywords
Schiff’s base ligand; 2-hydroxy-1-naphthaldehyde; spectral studies; molecular modeling; X-ray diffraction; antioxidant and antimicrobial activities
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