ROLE OF SOME COMPOUNDS IN AMELIORATING SOME HEMATOLOGICAL PARAMETERS AND LACTIC DEHYDROGENASE ACTIVITY IN RATS TREATED WITH ROSIGLITAZONE | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 4, Volume 19, Issue 2, December 2010, Page 30-38 PDF (2.61 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.2010.167385 | ||||
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| Authors | ||||
Ahmed Hendawy  ; Mansour Zahra; Reham Hamza
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| Zoology Department, Faculty of Science, Zagazig University, Zagazig . Egypt. | ||||
| Abstract | ||||
| The present study was carried out to evaluate some cardiovascular effect of Rosiglitazone, Nigella sativa, silymarin each alone and the combination of Rosiglitazone with either Nigella sativa or Silymarin in order to get the best combination to avoid the possible side effects produced by Rosiglitazone. This was done through studying the effect of the test plant drugs and their combination on some hematological parameters and hormone control on heart activity (Lactic dehydrogenase enzyme) (L.D.H) .seven groups of adult male rats each of 10 (200-250 gm / b. wt) were used in this study. Hyperglycemia was induced in six groups of rats. Whereas, the 7t group was left as normal control group. All treatments were given orally daily for successive 28 days .The 1st group was left without treatment and kept as STZ diabetic. The 2nd group was administered Rosiglitazone (0.58mg/100gm.b.wt) , The 3rd group was given Nigella sativa (0.25gm/100gm.b.wt) , the 4th group was given Silymarin (50mg/100gm.b.wt), the 5th and 6th groups were administered the combination of Rosiglitazone with either Nigella sativa or Silymarin respectively in the same recommended doses. Blood samples were collected after the 1st, 2nd, 3rd and 4th week post drug administration. Serum was separated and used for determination of various variables. The results showed that Rosiglitazone afforded a marked non significant changes in RBCS. WBCS with significant decrease in hemoglobin percent in Rosiglitazone treated group with marked increase in LDH hormone which reflect the activity of the heart when compared with diabetic non treated group and diabetic group treated with Rosiglitazone drug + Silymarin and Rosiglitazone drug + Nigella sativa. | ||||
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