The possible hypo-lipidemic effect of aqueous extract of gamma-irradiated chard leaves in rats fed high fat diet
Shaaban, A., EL-Shahat, A., Abdel-Azeem, A. (2021). The possible hypo-lipidemic effect of aqueous extract of gamma-irradiated chard leaves in rats fed high fat diet. EKB Journal Management System, 54(3), 46-54. doi: 10.21608/ajnsa.2021.48781.1414
Ashraf Mohamed Mounir Shaaban; Amro Nagah EL-Shahat; Aly Mohamed Abdel-Azeem. "The possible hypo-lipidemic effect of aqueous extract of gamma-irradiated chard leaves in rats fed high fat diet". EKB Journal Management System, 54, 3, 2021, 46-54. doi: 10.21608/ajnsa.2021.48781.1414
Shaaban, A., EL-Shahat, A., Abdel-Azeem, A. (2021). 'The possible hypo-lipidemic effect of aqueous extract of gamma-irradiated chard leaves in rats fed high fat diet', EKB Journal Management System, 54(3), pp. 46-54. doi: 10.21608/ajnsa.2021.48781.1414
Shaaban, A., EL-Shahat, A., Abdel-Azeem, A. The possible hypo-lipidemic effect of aqueous extract of gamma-irradiated chard leaves in rats fed high fat diet. EKB Journal Management System, 2021; 54(3): 46-54. doi: 10.21608/ajnsa.2021.48781.1414

The possible hypo-lipidemic effect of aqueous extract of gamma-irradiated chard leaves in rats fed high fat diet

Arab Journal of Nuclear Sciences and Applications
Article 6, Volume 54, Issue 3, July 2021, Page 46-54  XML PDF (900.07 K)
Document Type: Original Article
DOI: 10.21608/ajnsa.2021.48781.1414
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Authors
Ashraf Mohamed Mounir Shaaban email orcid 1; Amro Nagah EL-Shahat2; Aly Mohamed Abdel-Azeem3
1Food irradiation department, Artificial irradiation division, NCRRT, Cairo, Egypt
2Food irradiation Department, Artificial Irradiation Division, NCRRT, Cairo, Eygpt
3Food Irradiation Department, Artificial Irradiation, NCRRT, Cairo, Egypt
Abstract
Studying the influence of gamma (γ) -rays processing on the anti-oxidant activity of chard (Beta vulgaris) leaves and implementing of the conceivable hypo-lipidemic and anti-oxidant potential of aqueous extract of γ-irradiated chard leaves (GCLAE) against high fat diet (HFD) were the two objectives of this study. Processing of dried chard leaves by γ-rays (10 kGy) causeda significant elevation in the total phenolic content, total flavonoids and antioxidant activity compared tothe raw samples.Data showed that feeding rats HFD for 10 weeks induced a state of dyslipideamia, increase the levels of inflammatory factors, liver and cardiac markers and also induced the level of lipid peroxidation with significant depletion of the antioxidant status relative to the control group. Supplementation of GCLAE along with HFD resulted in remarkable protection against HFD-complications and that evidenced by reduction in total cholesterol (TC), triglycerides (TG),Low-density lipoprotein-cholesterol (LDL-C) and very Low-density lipoprotein-cholesterol(VLDL-C),remarkable increase in high-density lipoprotein cholesterol (HDL-C), tumor necrotic factor-alpha, interleukin-6, decrease the level of liver and cardiac enzymes and also GCLAE administration enhance the activity of hepatic and cardiac antioxidant parameters (glutathione content, superoxide dismutase and catalase) and reduce the level of malondialdehyde compared to rats fed HFD. Thus, it could be concluded that γ-irradiation technique might be useful for chard processing with the purpose of shelf-life prolongation as well as to increase its anti-oxidant capacity. Moreover, the results concluded that GCLAE may have an effective role in reducing the health complications for those fed high fat diet.
Keywords
Gamma-radiation; Beta vulgaris; high fat diet; inflammatory factors
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