Impact of maternal gestational diabetes on neutrophil functions of full term neonates
El-Gamal, Y., Abdou, R., Hamza, M., Saeid, H. (2017). Impact of maternal gestational diabetes on neutrophil functions of full term neonates. EKB Journal Management System, 15(2), 51-56. doi: 10.21608/ejpa.2017.16756
Yehia El-Gamal; Rania Abdou; Mohamed Hamza; Hayam Saeid. "Impact of maternal gestational diabetes on neutrophil functions of full term neonates". EKB Journal Management System, 15, 2, 2017, 51-56. doi: 10.21608/ejpa.2017.16756
El-Gamal, Y., Abdou, R., Hamza, M., Saeid, H. (2017). 'Impact of maternal gestational diabetes on neutrophil functions of full term neonates', EKB Journal Management System, 15(2), pp. 51-56. doi: 10.21608/ejpa.2017.16756
El-Gamal, Y., Abdou, R., Hamza, M., Saeid, H. Impact of maternal gestational diabetes on neutrophil functions of full term neonates. EKB Journal Management System, 2017; 15(2): 51-56. doi: 10.21608/ejpa.2017.16756

Impact of maternal gestational diabetes on neutrophil functions of full term neonates

The Egyptian Journal of Pediatric Allergy and Immunology
Article 2, Volume 15, Issue 2, October 2017, Page 51-56  XML PDF (427.85 K)
Document Type: Original Article
DOI: 10.21608/ejpa.2017.16756
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Authors
Yehia El-Gamal1; Rania Abdou2; Mohamed Hamza3; Hayam Saeid4
1Pediatric Allergy and Immunology Unit, Children’s Hospital, Ain Shams University, Cairo, Egypt
2Department of Pediatrics, Faculty of Medicine, Ain Shams University
3Department of Clinical Pathology, Ain Shams University
4Department of Pediatrics, Faculty of Medicine, Ain shams university, Cairo, Egypt
Abstract
Background: Maternal gestational diabetes is associated with an inflammatory environment that may contribute to fetal and placental inflammatory profile changes. Few studies investigated the effect of maternal gestational diabetes on neonatal innate immunity. Objectives: Our objective was to study neutrophil number and function in neonates born to mothers with gestational diabetes. Methods: Neutrophil number (complete blood count) and functions [CD11b, CD62L and Dihydrorhodamine 123 (DHR) by flow cytometry] were assessed in the cord blood of 30 full term neonates born to gestational diabetic mothers on insulin during pregnancy and another 15 born to healthy mothers as controls. Results: The mean total leucocytic and absolute neutrophil count were significantly lower in neonates of diabetics than in normal neonates (13.55± 2.51 and 17.89± 3.66 p> 0.001; 9.01±1.59 and 14.18±3.44 p>0.001 respectively). Mean CD11b, CD62L and DHR were lower among neonates of diabetic mothers than normal neonates (82.48± 8.09 & 87.85± 4.87 p < 0.05; 8.63±4.41 and 24.98±10.47 p <0.001; 68.71± 10.24 and 79.57±8.64 p< 0.001 respectively). Unlike the control neonates, neonates of gestational diabetic mothers had positive correlation between the functional neutrophil parameters (r0.39 p<0.05). Conclusion: Gestational diabetes affects cord blood neutrophil count and functions leading to high susceptibility to infection.
Keywords
Gestational; Diabetes mellitus; Neutrophils
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