Lymphocyte subtype dysregulation in a group of children with simple obesity
El-Sayed, H., El-Gendy, Y., Radwan, N., Farweez, B., Fouda, S. (2017). Lymphocyte subtype dysregulation in a group of children with simple obesity. EKB Journal Management System, 15(2), 63-68. doi: 10.21608/ejpa.2017.16758
Hoda El-Sayed; Yasmine El-Gendy; Nesrine Radwan; Botheina Farweez; Shaimaa Fouda. "Lymphocyte subtype dysregulation in a group of children with simple obesity". EKB Journal Management System, 15, 2, 2017, 63-68. doi: 10.21608/ejpa.2017.16758
El-Sayed, H., El-Gendy, Y., Radwan, N., Farweez, B., Fouda, S. (2017). 'Lymphocyte subtype dysregulation in a group of children with simple obesity', EKB Journal Management System, 15(2), pp. 63-68. doi: 10.21608/ejpa.2017.16758
El-Sayed, H., El-Gendy, Y., Radwan, N., Farweez, B., Fouda, S. Lymphocyte subtype dysregulation in a group of children with simple obesity. EKB Journal Management System, 2017; 15(2): 63-68. doi: 10.21608/ejpa.2017.16758

Lymphocyte subtype dysregulation in a group of children with simple obesity

The Egyptian Journal of Pediatric Allergy and Immunology
Article 4, Volume 15, Issue 2, October 2017, Page 63-68  XML PDF (434.11 K)
Document Type: Original Article
DOI: 10.21608/ejpa.2017.16758
View on SCiNiTO View on SCiNiTO
Authors
Hoda El-Sayed1; Yasmine El-Gendy1; Nesrine Radwan1; Botheina Farweez2; Shaimaa Fouda3
1Departments of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: Obesity as a global public health problem is increasing in prevalence. Reports showed that obese children are more liable to infection than lean ones; it was claimed that obese subjects have altered peripheral blood total lymphocyte counts in addition to reduced lymphocyte proliferative response to mitogen stimulation as well as dysregulated cytokine expression. Objective: This study aimed to evaluate the effect of childhood obesity on cell mediated immunity as indicated by peripheral blood lymphocyte phenotyping. Methods: We enrolled 30 school-aged children (mean age 10±3.27 years). They comprised two groups; 20 obese children with a mean body mass index (BMI) of 39.2± 12.5 and 10 matched control subjects with mean BMI of 18.4± 1.9. They were subjected to detailed anthropometric evaluation including weight, height, and waist hip ratio in addition to calculation of BMI, complete blood counting, and flow cytometric assessment of T-helper (CD4), T-cytotoxic/suppressor (CD8), and natural killer (CD56) cell counts . Results: The absolute lymphocyte (CD3) and natural killer cell (CD56) counts were comparable in both groups. However, the CD4%, CD8%, CD4/CD8 ratio were significantly lower in the obese children (p=0.02, 0.03, 0.015 respectively). A significant negative correlation could be elicited between the CD4 count and bodyweight, BMI, and hip waist ratio (p = 0.00); the same was observed for CD4/CD8 ratio (p = 0.00). On the contrary, CD8 correlated positively to the bodyweight, BMI, and waist hip ratio (p = 0.00 for each). Conclusion: Obesity has an impact on lymphocytic subset counts and further studies are needed to assess its effect on their function.
Keywords
obesity, children immunology; CD Markers; lymphocytes; BMI
Statistics
Article View: 154
PDF Download: 202