Role of Maternal Serum Procalcitonin, Interleukin-6 and hs-C Reactive Protein in Prediciton of Subclinical (Intrauterine) Infection in Preterm Premature Rupture of Membranes
Abd Elmegeed, A., Abd Elreheem, S., Abd Ellatif, A., Hamdy, I., Ebrahem, E. (2011). Role of Maternal Serum Procalcitonin, Interleukin-6 and hs-C Reactive Protein in Prediciton of Subclinical (Intrauterine) Infection in Preterm Premature Rupture of Membranes. EKB Journal Management System, 42(1), 12-20. doi: 10.21608/ejhm.2011.16788
Amany M.E. Abd Elmegeed; Sabah I. Abd Elreheem; Al-Shimaa Allam Abd Ellatif; Inas Mahmoud Hamdy; Eman El-Shohat Ebrahem. "Role of Maternal Serum Procalcitonin, Interleukin-6 and hs-C Reactive Protein in Prediciton of Subclinical (Intrauterine) Infection in Preterm Premature Rupture of Membranes". EKB Journal Management System, 42, 1, 2011, 12-20. doi: 10.21608/ejhm.2011.16788
Abd Elmegeed, A., Abd Elreheem, S., Abd Ellatif, A., Hamdy, I., Ebrahem, E. (2011). 'Role of Maternal Serum Procalcitonin, Interleukin-6 and hs-C Reactive Protein in Prediciton of Subclinical (Intrauterine) Infection in Preterm Premature Rupture of Membranes', EKB Journal Management System, 42(1), pp. 12-20. doi: 10.21608/ejhm.2011.16788
Abd Elmegeed, A., Abd Elreheem, S., Abd Ellatif, A., Hamdy, I., Ebrahem, E. Role of Maternal Serum Procalcitonin, Interleukin-6 and hs-C Reactive Protein in Prediciton of Subclinical (Intrauterine) Infection in Preterm Premature Rupture of Membranes. EKB Journal Management System, 2011; 42(1): 12-20. doi: 10.21608/ejhm.2011.16788

Role of Maternal Serum Procalcitonin, Interleukin-6 and hs-C Reactive Protein in Prediciton of Subclinical (Intrauterine) Infection in Preterm Premature Rupture of Membranes

The Egyptian Journal of Hospital Medicine
Article 2, Volume 42, Issue 1, January 2011, Page 12-20  XML PDF (227.52 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2011.16788
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Authors
Amany M.E. Abd Elmegeed1; Sabah I. Abd Elreheem1; Al-Shimaa Allam Abd Ellatif2; Inas Mahmoud Hamdy2; Eman El-Shohat Ebrahem3
1Clinical Pathology Departments, Al-Azhar University Faculty of Medicine for girls
2Obstetrics and Gynecology Departments, Al-Azhar University Faculty of Medicine for girls
3Medical Biochemistry Departments, Al-Azhar University Faculty of Medicine for girls
Abstract
Objective:
To evaluate the role of procalcitonin (PCT), high senstive C-reactive protein (hs-CRP) and Interleukin-6 (IL-6) for prediction of subclinical intrauterine infection in pregnant women with preterm premature rupture of membranes.
 
Methods:
Twenty patients with preterm premature rupture of membranes PPROM (study group) and twenty apparently healthy pregnant women (control) group between 26-34 weeks of pregnancy were enrolled in this study.
In all cases analysis of serum procalcitonin by high performance liquid chromatography, Il-6 by ELISA method and hs-CRP by nephelometry were done. Culture of vaginal bacteria was done for study group only.
 
Results:
Procalcitonin levels in the PRROM group were significantly higher than in healthy pregnant women (median 1.95 versus 0.39-Interquartile range 1.375 versus 0.213 – P0.001). A significant correlation was observed between PCT and hs-CRP (r=0.510; P0.031) and leucocytosis (r=0.544- P 0.013). Also IL-6 levels were significantly higher in cases of PPROM compared with control group (median 40.01 versus 5.55 – Interquartile range, 45.88 versus
4.22 P 0.001). No significant correlation was present  between PCT and IL-6
 
Conclusion:
Determination of PCT, hs-CRP and IL-6 in mother's blood sample can be useful for diagnostics of PPROM cases suspected of intrauterine infection. However PCT more valuable and specific.
 
 
 
Keywords
Preterm premature rupture membranes; Procalcitonin: Interleukin – 6; high sensitive C-reactive protein
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