Role of Diffusion-Weighted Magnetic Resonance Imaging in Laryngeal and Hypopharyngeal Cancer in Comparison to Histopathological Finding | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 90, Volume 83, Issue 1, April 2021, Page 1392-1399 PDF (423.86 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2021.168261 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hagar A. Abdel-Muttalib  1; Essam A. Behairy1; Ahmad M. Hamadan1; Naser M. Abd El-Bary2; Mohammed E Abd El-Samea3
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| 1Departments of 1Otorhinolaryngology National liver Institute, Menoufia University, Egypt | ||||
| 2Clinical Oncology, Faculty of Medicine, , National liver Institute, Menoufia University, Egypt | ||||
| 3Department of Diagnostic Medical and Interventional Radiology, National liver Institute, Menoufia University, Egypt | ||||
| Abstract | ||||
| Background: Diffusion-weighted magnetic resonance imaging (DW-MRI) has the ability of tissue characterization and can differentiate between benign and malignant tissues, including differentiation between benign post-radiotherapy changes and residual or recurrent malignancy. Objective: This study aimed to assess the role of diffusion-weighted magnetic resonance imaging in the evaluation of laryngeal and hypopharyngeal cancer as an initial diagnosis and the post-treatment surveillance protocol. Patients and methods: This study was a cross-sectional analytical study including twenty-five patients who presented with laryngeal or hypopharyngeal masses, thirteen cases were pretreatment cases, and twelve cases were post-treatment cases after completion of treatment. Seven cases had a hypopharyngeal origin, and eighteen cases had a laryngeal origin. The patients were assessed using history taking, a telescopic examination of the larynx and hypopharynx, computed tomography scanning, and diffusion-weighted magnetic resonance imaging on the neck. Direct laryngoscopic examination and biopsy taking from suspicious lesions were done. Biopsies were subjected to histopathological examination with a correlation between pathological and DW- MRI radiological results. Results: DW-MRI had a 100% sensitivity, 82.4 % specificity, and 88% accuracy compared to histopathological findings of biopsies from the studied group. There was a non-significant difference between DW-MRI and biopsy findings for either pretreatment or post-treatment cases of both laryngeal and hypopharyngeal origin of the lesions (p-value > 0.05 for all). Conclusion: DW-MRI is a sensitive tool for detecting laryngeal and hypopharyngeal cancers in new cases and excluding tumor residual after chemo-radiotherapy in cases with suspicious lesions after completion of treatment. | ||||
| Keywords | ||||
| Apparent Diffusion Coefficient; Chemotherapy; Diffusion-Weighted MRI; Laryngeal cancer; Hypopharyngeal cancer; Radiotherapy | ||||
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