Impact--оf Urinary Growth Norifonё/Insplin-Like Growth Factor-I on The Development of Nephropathy in Early-Onset and Long-Term Diabetic Children
El-Morshedy, S., Abd Al Hamid, E., Imam, A., Karam, R., Ajamy, A. (2011). Impact--оf Urinary Growth Norifonё/Insplin-Like Growth Factor-I on The Development of Nephropathy in Early-Onset and Long-Term Diabetic Children. EKB Journal Management System, 11(1), 1-9. doi: 10.21608/geget.2011.16888
Salah El-Morshedy; Ehab Abd Al Hamid; A. Basset Imam; Rehab Karam; Ahmed Ajamy. "Impact--оf Urinary Growth Norifonё/Insplin-Like Growth Factor-I on The Development of Nephropathy in Early-Onset and Long-Term Diabetic Children". EKB Journal Management System, 11, 1, 2011, 1-9. doi: 10.21608/geget.2011.16888
El-Morshedy, S., Abd Al Hamid, E., Imam, A., Karam, R., Ajamy, A. (2011). 'Impact--оf Urinary Growth Norifonё/Insplin-Like Growth Factor-I on The Development of Nephropathy in Early-Onset and Long-Term Diabetic Children', EKB Journal Management System, 11(1), pp. 1-9. doi: 10.21608/geget.2011.16888
El-Morshedy, S., Abd Al Hamid, E., Imam, A., Karam, R., Ajamy, A. Impact--оf Urinary Growth Norifonё/Insplin-Like Growth Factor-I on The Development of Nephropathy in Early-Onset and Long-Term Diabetic Children. EKB Journal Management System, 2011; 11(1): 1-9. doi: 10.21608/geget.2011.16888

Impact--оf Urinary Growth Norifonё/Insplin-Like Growth Factor-I on The Development of Nephropathy in Early-Onset and Long-Term Diabetic Children

GEGET
Article 1, Volume 11, Issue 1, December 2011, Page 1-9  XML PDF (985.13 K)
Document Type: Original Article
DOI: 10.21608/geget.2011.16888
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Authors
Salah El-Morshedy1; Ehab Abd Al Hamid1; A. Basset Imam2; Rehab Karam1; Ahmed Ajamy3
1Department of Medical Biochemistry, Faculty of Medicine; Z.agazig University, Egypt.
2Department of Medical Biochemistry, Faculty of Medicine; Z.agazig University, Egyp
3Departments of Pediatrics and Radiology King Abdulaziz University Hospital, Jeddah
Abstract
Background: Growth hormone' (Gil), insuImn-1mke growth factor-I (1G1'-1), 1GF-binding protein (GHJIGF/ IGFBP) axis has been suggested bothţо'maintain.normal renal function and to play an important role in the development of diabetic nephropathy (DN), in patients with type I diabetes (TI D). Nephromegaly (NM) and microalbuminuria (МА) are early markers of DN.
Objective: Study the role of urinary concentrations of GH and IGF-I in the development of DN, in children and adolescents suffering T ID.
Study design: A total of 50 children and adolescents with TI D of 6-14 years old were recruited from the Pediatric Diabetes Clinic at King Abdulaziz University Hospital, 23 were males and 27 were females. Subjects were divided into two groups; 20 with early-onset diabetes and 30 with long-term diabetes. Both groups were subjected to history-taking, clinical examination including body mass index (BM1), pubertal staging according to the rating of Tannег , assessment of glycemic control, measurement of kidney volume (KV), as a marker of glomerular hypertrophy, by ultrasonography (U/S).
Results: The overall rate of МА and NM accounted for 20% (10/50) and 26% (13/50), respectively, being more detected in long-term diabetics than that in patients with early-onset diabetes, with significant difference. Long-term diabetics had significantly higher albumin excretion rate (AER) and urinary GH and IGF-1 concentrations than that in early-onset diabetics. The mean BMI, pubertal duration, urinary GH and urinary IGF-1 were significantly higher among diabetics positive for MA than that among diabetics negative for hМА.
Conclusion: Our data, which reflect increased mean urinary GH/IGF-1 production, strengthen the evidence of an association between GH, МА, NM and also implicate urinary G1l/IGF-I in DN, particularly in children and adolescents with long-term diabetes, increased pubertal duration and poor glycemic control.
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