PREPARATION AND CHARACTERIZATION OF DERMAL FILMS CONTAINING AN ANTI- INFLAMMATORY DRUG | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 4, Volume 18, Issue 1, June 2009, Page 30-39 PDF (2.41 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.2009.169355 | ||||
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| Authors | ||||
Saleh Abd El-Rasoul1; Sayed Auda  2
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| 1Department of Pharmaceutics and Industrial Pharmacy. Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt | ||||
| 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt. | ||||
| Abstract | ||||
| Piroxicam is a potent nonsteroidal anti-inflammatory drug associated with many side effects when taken orally. An attention was paid in this work to formulate and characterize piroxicam containing polymer films for dermal use. The used polymers were cellulose types namely ethylcellulos (EC) and hydroxypropy1 methylcellulos (HPMC). In this study, medicated films consısting of drug and carrier were prepared The carrier consisted of one or two polymers The physicochemical characterization was done by IR spectroscopy, DSC and X-Ray diffractometry for both piroxicam polymeric films and their corresponding physical mixtures as well as the untreated drug and polymer powders to investigate the drug polymer interaction The results showed absence of molecular interactions between piroxicam and both EC and HPMC. In-vitro drug release from these polymer films was studied It is found that when the ratio of HPMC increased the drug release from the film become faster | ||||
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