INVESTIGATION OF THE CURATIVE EFFECTS OF SILYMARIN, CURCUMIN AND TAURINE ON CCI4-INDUCED LIVER CIRRHOSIS IN RATS
Elshazly, S., Zakaria, M., Ahmed, A., Mohamed, M. (2008). INVESTIGATION OF THE CURATIVE EFFECTS OF SILYMARIN, CURCUMIN AND TAURINE ON CCI4-INDUCED LIVER CIRRHOSIS IN RATS. EKB Journal Management System, 17(2), 17-24. doi: 10.21608/zjps.2008.169365
Shimaa Elshazly; Mohamed Zakaria; Ahmed Ahmed; Mohamed Mohamed. "INVESTIGATION OF THE CURATIVE EFFECTS OF SILYMARIN, CURCUMIN AND TAURINE ON CCI4-INDUCED LIVER CIRRHOSIS IN RATS". EKB Journal Management System, 17, 2, 2008, 17-24. doi: 10.21608/zjps.2008.169365
Elshazly, S., Zakaria, M., Ahmed, A., Mohamed, M. (2008). 'INVESTIGATION OF THE CURATIVE EFFECTS OF SILYMARIN, CURCUMIN AND TAURINE ON CCI4-INDUCED LIVER CIRRHOSIS IN RATS', EKB Journal Management System, 17(2), pp. 17-24. doi: 10.21608/zjps.2008.169365
Elshazly, S., Zakaria, M., Ahmed, A., Mohamed, M. INVESTIGATION OF THE CURATIVE EFFECTS OF SILYMARIN, CURCUMIN AND TAURINE ON CCI4-INDUCED LIVER CIRRHOSIS IN RATS. EKB Journal Management System, 2008; 17(2): 17-24. doi: 10.21608/zjps.2008.169365

INVESTIGATION OF THE CURATIVE EFFECTS OF SILYMARIN, CURCUMIN AND TAURINE ON CCI4-INDUCED LIVER CIRRHOSIS IN RATS

Zagazig Journal of Pharmaceutical Sciences
Article 3, Volume 17, Issue 2, December 2008, Page 17-24  XML PDF (2.66 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2008.169365
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Authors
Shimaa Elshazly email 1; Mohamed Zakaria2; Ahmed Ahmed3; Mohamed Mohamed3
1Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
3Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Abstract
The present study was designed to clarify the effects of silymarin, taurine and curcumin on hepatic toxicity in rats. Hepatic toxicity was induced with carbon tetrachloride (25 µl /100gn) I.P. 3 times /weekly for 6 weeks. Rats were treated with silymarin (100 mg/kg), taurine (1 gm/kg) and curcumin (75 mg/kg) for 30 days after induction of hepatic toxicity. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phoshatase (ALP), blood glucose, total protein and albumin activities were determined, in addition to histopathological examination. Plasma ALT, AST, ALP and blood glucose activities were increased in CCI, treated rats, in addition to reduction in the level of total protein, albumin and globulin. Histopathological examination showed mono-lobular cirrhosis, represented by fibrous tissue encircling individual hepatic lobules, in addition, the portal triads showed extensive cirrhosis with round cells infiltration. Treatment of cirrhotic rats with taurine, silymarin or curcumin showed a significant reduction in ALT, AST and ALP levels. However the previous mentioned drugs caused a significant increase in the level of total protein, albumin and A/G ratio. Oral treatment of cirrhotic rats with silymarin showed remnants of portal fibrosis. However, liver of curcumin or taurine treated rats were apparently normal. Cirrhotic rats treated with curcumin or taurine showed more pronounced effect on ALT, AST, ALP and proteins than silymarin.
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