SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 5, Volume 16, Issue 2, December 2007, Page 35-38 PDF (1.15 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.2007.169387 | ||||
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Authors | ||||
Mohamed Said 1; Nagat Ghareb1; Adel El-Gendy2 | ||||
1Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. | ||||
2Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. | ||||
Abstract | ||||
Condensation of 4-chlorophenylhydrazine (1) with ethyl pyruvate led to the formation of ethy1 pyruvate 4- chlorophenyl thydrazone (2) Fischer Indolization of (2) gave ethyl 5-chloro-1H-indole-2-carboxylate (3). Vilsmeier-Hacck formylation of (3) gave ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate (4). The reaction of (4) with substituted anilines led to the formation of ethytl 3-(N-aryliminomethyl)-5-chloro-1H-indole-2-carboxylate (5-10). Structures of the new compounds were confirmed by both analytical and spectral data (IR, NMR and MS). Antimicrobial screening was also performed. | ||||
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