OCULAR BIOAVAILABILITY OF ENROFLOXACIN-CYCLODEXTRIN COMPLEXES FROM CERTAIN OPHTHALMIC PREPARATIONS IN RABBITS EYES
Abd El-Aleem, H., Ramadan, E., Soliman, O., Kheira, S., El-Dahhan, M. (2006). OCULAR BIOAVAILABILITY OF ENROFLOXACIN-CYCLODEXTRIN COMPLEXES FROM CERTAIN OPHTHALMIC PREPARATIONS IN RABBITS EYES. EKB Journal Management System, 15(1), 23-30. doi: 10.21608/zjps.2006.169416
Hamdy Abd El-Aleem; Esmail Ramadan; Osama Soliman; Samy Kheira; Marwa El-Dahhan. "OCULAR BIOAVAILABILITY OF ENROFLOXACIN-CYCLODEXTRIN COMPLEXES FROM CERTAIN OPHTHALMIC PREPARATIONS IN RABBITS EYES". EKB Journal Management System, 15, 1, 2006, 23-30. doi: 10.21608/zjps.2006.169416
Abd El-Aleem, H., Ramadan, E., Soliman, O., Kheira, S., El-Dahhan, M. (2006). 'OCULAR BIOAVAILABILITY OF ENROFLOXACIN-CYCLODEXTRIN COMPLEXES FROM CERTAIN OPHTHALMIC PREPARATIONS IN RABBITS EYES', EKB Journal Management System, 15(1), pp. 23-30. doi: 10.21608/zjps.2006.169416
Abd El-Aleem, H., Ramadan, E., Soliman, O., Kheira, S., El-Dahhan, M. OCULAR BIOAVAILABILITY OF ENROFLOXACIN-CYCLODEXTRIN COMPLEXES FROM CERTAIN OPHTHALMIC PREPARATIONS IN RABBITS EYES. EKB Journal Management System, 2006; 15(1): 23-30. doi: 10.21608/zjps.2006.169416

OCULAR BIOAVAILABILITY OF ENROFLOXACIN-CYCLODEXTRIN COMPLEXES FROM CERTAIN OPHTHALMIC PREPARATIONS IN RABBITS EYES

Zagazig Journal of Pharmaceutical Sciences
Article 4, Volume 15, Issue 1, June 2006, Page 23-30  XML PDF (1.88 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2006.169416
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Authors
Hamdy Abd El-Aleem email 1; Esmail Ramadan1; Osama Soliman2; Samy Kheira3; Marwa El-Dahhan1
1Department of Pharmaceutics, Faculty of Pharmacy. Mansoura University, Mansoura, 35516, Egypt.
2Department of Pharmaceutics Faculty of pharmacy. Mansoura University, Mansour. 35516. Egypt.
3Department of Microbiology, Faculty of Pharmacy. Mansoura University, Mansoura, 35516, Egypt.
Abstract
The effect of inclusion complexes of enrofloxacin (Enr) with cyclodextrins (CyDs): hydroxypropyl beta-cyclodextrin (HP-β -CYD) and beta-cyclodextrin (β -CyD) was studied. These complexes were prepared in a molar ratio (1:2). The ophthalmic gels [sodium carboxymethyl cellulose (sod CMC), sodium alginate] and ointments (emulsion, absorption and water soluble bases) were prepared using 0. 5% of the drug or equivalent amounts of its complexes with HP- β -CyD or β -CyD. The ocular disposition of the drug in rabbit's eyes has been studied.
The obtained results revealed that, all tested formulations provided the highest Cmax of the drug in conjunctiva followed by Cornea, iris-ciliary body, and then aqueous humor .The peak time of maximum drug concentration in rabbit's eye tissues and aqueous humor was two hours for various ophthalmic ointments and gels The total availability of enrofloxacin was improved when the drug was complexed with HP-β –CYD.
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