DESIGN, SYNTHESIS AND MOLECULAR MODELING OF CERTAIN IMIDAZO AND OXAZOLOPYRIDINE DERIVATIVES OF BIOLOGICAL INTEREST
Abdelall, E., El-Badry, O., Roshdy, S., El-Enany, M. (2006). DESIGN, SYNTHESIS AND MOLECULAR MODELING OF CERTAIN IMIDAZO AND OXAZOLOPYRIDINE DERIVATIVES OF BIOLOGICAL INTEREST. EKB Journal Management System, 15(2), 38-52. doi: 10.21608/zjps.2006.169425
Eman Abdelall; Osama El-Badry; Sameha Roshdy; Mervat El-Enany. "DESIGN, SYNTHESIS AND MOLECULAR MODELING OF CERTAIN IMIDAZO AND OXAZOLOPYRIDINE DERIVATIVES OF BIOLOGICAL INTEREST". EKB Journal Management System, 15, 2, 2006, 38-52. doi: 10.21608/zjps.2006.169425
Abdelall, E., El-Badry, O., Roshdy, S., El-Enany, M. (2006). 'DESIGN, SYNTHESIS AND MOLECULAR MODELING OF CERTAIN IMIDAZO AND OXAZOLOPYRIDINE DERIVATIVES OF BIOLOGICAL INTEREST', EKB Journal Management System, 15(2), pp. 38-52. doi: 10.21608/zjps.2006.169425
Abdelall, E., El-Badry, O., Roshdy, S., El-Enany, M. DESIGN, SYNTHESIS AND MOLECULAR MODELING OF CERTAIN IMIDAZO AND OXAZOLOPYRIDINE DERIVATIVES OF BIOLOGICAL INTEREST. EKB Journal Management System, 2006; 15(2): 38-52. doi: 10.21608/zjps.2006.169425

DESIGN, SYNTHESIS AND MOLECULAR MODELING OF CERTAIN IMIDAZO AND OXAZOLOPYRIDINE DERIVATIVES OF BIOLOGICAL INTEREST

Zagazig Journal of Pharmaceutical Sciences
Article 5, Volume 15, Issue 2, December 2006, Page 38-52  XML PDF (3.67 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2006.169425
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Authors
Eman Abdelall email 1; Osama El-Badry2; Sameha Roshdy2; Mervat El-Enany2
1Organic Chemistry Department, Faculty of Pharmacy, Beni Sueif University, Beni Sueif , Egypt
2Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo
Abstract
  2-(4- Amino-3-subsituted and unsubsituted phenyl) imidazo and/or oxazolo )[4,5-b] pyridines la-h were diazotized to afford II. Coupling of the latter with diethylmalonate afforded llla,b while its coupling with malononitrile afforded VIa-d . the pyrazolo derivatives IVa-d, the pyrimido derivatives IVa-d were obtained when llla,b were cyclized with hydrazine, phenyl hydrazine , urea and thiourea respectively. The aminopyrazolo derivatives Vlla-d were obtained by cyclization of VIa-d with hydrazine. In addition a number of azo dyes were also synthesized. Another series of schiff,s bases were prepared from the reaction of Ia-h with different substituted benzaldhydes , then a novel series of cyclized compounds Xa-d and XIa-d were obtained by reaction of certain azomethine with chloroacetyl chloride and mercaptoacetic acid respectively. Molecular modeling and antimicrobial activity for some of the synthesized compounds were also involved.
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