Ultrastructure alterations of retinal photoreceptors of the black rat, Rattus rattus exposed to certain heavy metals
El-Dawi, E., Naguib, N. (2010). Ultrastructure alterations of retinal photoreceptors of the black rat, Rattus rattus exposed to certain heavy metals. EKB Journal Management System, 41(1), 456-469. doi: 10.21608/ejhm.2010.16946
Elsayed F. A. El-Dawi; Naima I. Naguib. "Ultrastructure alterations of retinal photoreceptors of the black rat, Rattus rattus exposed to certain heavy metals". EKB Journal Management System, 41, 1, 2010, 456-469. doi: 10.21608/ejhm.2010.16946
El-Dawi, E., Naguib, N. (2010). 'Ultrastructure alterations of retinal photoreceptors of the black rat, Rattus rattus exposed to certain heavy metals', EKB Journal Management System, 41(1), pp. 456-469. doi: 10.21608/ejhm.2010.16946
El-Dawi, E., Naguib, N. Ultrastructure alterations of retinal photoreceptors of the black rat, Rattus rattus exposed to certain heavy metals. EKB Journal Management System, 2010; 41(1): 456-469. doi: 10.21608/ejhm.2010.16946

Ultrastructure alterations of retinal photoreceptors of the black rat, Rattus rattus exposed to certain heavy metals

The Egyptian Journal of Hospital Medicine
Article 1, Volume 41, Issue 1, October 2010, Page 456-469  XML PDF (1.47 MB)
Document Type: Original Article
DOI: 10.21608/ejhm.2010.16946
View on SCiNiTO View on SCiNiTO
Authors
Elsayed F. A. El-Dawi1; Naima I. Naguib2
1Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt
2Health Radiation Research Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt
Abstract
Aim of work: This study was designed to investigate the impact of lead and cadmium on the
retinal photoreceptors of rats.
Material &Methods: Adult black rats, Rattus rattus, were selected and divided into control and exposed groups. The exposed group was housed in industrial car batteries room containing fumes of lead and cadmium. The retina prepared for scanning and transmission electron microscopy.
Results: The scanning electron microscopy revealed different lead-cadmium changes represented by gradual increasing in spaces between segments of the photoreceptors, associated with swelling of their inner segments and accompanied with rupture, degeneration and decreased numbers of some rods and cones in the outer segments. Disorganization, shortening, a decrease in number of the photoreceptors and a great deformity were the characteristic changes after prolonged exposure to the heavy metals. The aforementioned damages of the photoreceptors were confirmed at the ultrastructural level using transmission electron microscope in the form of progressive disorganization, shortening, swelling, widening of the intradiscal spaces, vacuolization and degeneration of the lamellae of the outer segments (OS), followed by the damage of mitochondria of the inner segments(IS). Excessive penetration of the processes of the pigmented epithelium (PE) filled with pigments of different shapes and sizes between the damaged segments were noted. These pathological changes were considered the first symptoms in the retinal toxicity.
Conclusion: The present results are alarming and call for further investigations to elucidate the impact of exposure to these heavy metals for longer periods on the rat vision and eye structure.
 
Keywords
Photoreceptors; SEM; TEM; Heavy metals; Rats
Statistics
Article View: 136
PDF Download: 318