NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS
Lashine, E. (1992). NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS. EKB Journal Management System, 1(2), 85-93. doi: 10.21608/zjps.1992.169730
El-Sayed Lashine. "NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS". EKB Journal Management System, 1, 2, 1992, 85-93. doi: 10.21608/zjps.1992.169730
Lashine, E. (1992). 'NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS', EKB Journal Management System, 1(2), pp. 85-93. doi: 10.21608/zjps.1992.169730
Lashine, E. NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS. EKB Journal Management System, 1992; 1(2): 85-93. doi: 10.21608/zjps.1992.169730

NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS

Zagazig Journal of Pharmaceutical Sciences
Article 1, Volume 1, Issue 2, December 1992, Page 85-93  XML PDF (4.14 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1992.169730
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Author
El-Sayed Lashine email
Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Abstract
New O-aminonitriles (enaminonitriles) namely, pyrimido[1,6-a] indole were prepared by addition of 2-dicyanome thylidinoindoline-obtained from oxindole- to various isothiocyanates. The obtained enaminonitriles were acylated using chloroacetylchloride yielding methylchloride derivatives of the condensed pyrimidines, pyrimido (4,5 :4,5] pyrimido[1,6-a] indole. The chlorine atom was substituted by different amines or condensed with thiourea and the formed salts were hydrolyzed to give mercaptoalkyl compounds. Some of the prepared compounds were tested for their analgetic activities.
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