Anti- Müllarian hormone (AMH) as an indicator of ovarian reserve in acne patients treated with isotretinoin
Ibrahim, M., Abdel-Khalik, G., Soliman, A., Haroun, A. (2021). Anti- Müllarian hormone (AMH) as an indicator of ovarian reserve in acne patients treated with isotretinoin. EKB Journal Management System, 6(3), 69-72. doi: 10.21608/bjas.2021.169815
M.A. Ibrahim; G.M. Abdel-Khalik; A.S. Soliman; A.M. Haroun. "Anti- Müllarian hormone (AMH) as an indicator of ovarian reserve in acne patients treated with isotretinoin". EKB Journal Management System, 6, 3, 2021, 69-72. doi: 10.21608/bjas.2021.169815
Ibrahim, M., Abdel-Khalik, G., Soliman, A., Haroun, A. (2021). 'Anti- Müllarian hormone (AMH) as an indicator of ovarian reserve in acne patients treated with isotretinoin', EKB Journal Management System, 6(3), pp. 69-72. doi: 10.21608/bjas.2021.169815
Ibrahim, M., Abdel-Khalik, G., Soliman, A., Haroun, A. Anti- Müllarian hormone (AMH) as an indicator of ovarian reserve in acne patients treated with isotretinoin. EKB Journal Management System, 2021; 6(3): 69-72. doi: 10.21608/bjas.2021.169815

Anti- Müllarian hormone (AMH) as an indicator of ovarian reserve in acne patients treated with isotretinoin

Benha Journal of Applied Sciences
Article 13, Volume 6, Issue 3, May and June 2021, Page 69-72  XML PDF (450.67 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2021.169815
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Authors
M.A. Ibrahim1; G.M. Abdel-Khalik2; A.S. Soliman3; A.M. Haroun1
1Dermatology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
21Dermatology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
3Gynecology and Obstetrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
Background: Isotretinoin suppresses sebum development by inducing sebocyte apoptosis, which is induced by the expression of tumour necrosis factor-related apoptosis-inducing ligand, insulin-like growth factor binding protein-3, and neutrophil gelatinase-associated lipocalin, which is induced by isotretinoin. While apoptosis could play a role in the drug's key mechanism of action, it may also be to blame for the majority of isotretinoin's side effects, including ovarian reserve impairment. The aim of this study was to see if AMH could be used as a measure of ovarian reserve in isotretinoin-treated acne patients. The participants in this study were 66 female patients in their reproductive years who had various degrees of acne. All of the patients were chosen from the Dermatology and Andrology Department of Benha University Hospitals' outpatient clinic. The research lasted anywhere from 6 to 12 months. The average age of the patients in this study was 25 years, with a standard deviation of 6 years. There was no substantial difference in AMH before and after Isotretinoin therapy. The percentage change in AMH after treatment had no important relationship with the patients' age, Isotretinoin dosage, or treatment period. Isotretinoin has a negative impact on the ovaries, according to the findings. More research is required to gain a better understanding of this subject and to see if the effects are permanent.
Keywords
Anti-Müllarian; AMH; ovarian; acne; isotretinoin
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