Nematicidal Potential Impact of Phosphodiesterase (PDE) Inhibitors against Root-Knot Nematode, Meloidogyne incognita.
M., R., F., A., Ali, F., A., M. (2018). Nematicidal Potential Impact of Phosphodiesterase (PDE) Inhibitors against Root-Knot Nematode, Meloidogyne incognita.. EKB Journal Management System, 10(1), 85-90. doi: 10.21608/eajbsf.2018.17022
Raddy H. M.; Abdel-Lateef M. F.; Fouad A. F. Ali; Montasser S. A.. "Nematicidal Potential Impact of Phosphodiesterase (PDE) Inhibitors against Root-Knot Nematode, Meloidogyne incognita.". EKB Journal Management System, 10, 1, 2018, 85-90. doi: 10.21608/eajbsf.2018.17022
M., R., F., A., Ali, F., A., M. (2018). 'Nematicidal Potential Impact of Phosphodiesterase (PDE) Inhibitors against Root-Knot Nematode, Meloidogyne incognita.', EKB Journal Management System, 10(1), pp. 85-90. doi: 10.21608/eajbsf.2018.17022
M., R., F., A., Ali, F., A., M. Nematicidal Potential Impact of Phosphodiesterase (PDE) Inhibitors against Root-Knot Nematode, Meloidogyne incognita.. EKB Journal Management System, 2018; 10(1): 85-90. doi: 10.21608/eajbsf.2018.17022

Nematicidal Potential Impact of Phosphodiesterase (PDE) Inhibitors against Root-Knot Nematode, Meloidogyne incognita.

Egyptian Academic Journal of Biological Sciences, F. Toxicology & Pest Control
Article 8, Volume 10, Issue 1, June 2018, Page 85-90  XML PDF (514.63 K)
Document Type: Original Article
DOI: 10.21608/eajbsf.2018.17022
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Authors
Raddy H. M.1; Abdel-Lateef M. F.1; Fouad A. F. Ali1; Montasser S. A.2
1Department of Plant Protection, Faculty of Agriculture, Al-Azhar University, Egypt
2Department of Agricultural Zoology and Nematology, Faculty of Agriculture, Al-Azhar University, Egypt
Abstract
Soon after the discovery that phosphodiesterase (PDEs) are presented in nematodes and regulate the signaling pathway responsible for its motility and reproduction, many of PDE inhibitors have been examined for their nematicidal effects. The present study evaluates the nematicidal activity of seven commercial drugs that act as PDE inhibitors namely diazepam, papaverine, theophylline, caffeine, cilostazol, vinpocetine and sildenafil against root-knot nematodes (Meloidogyne incognita) under laboratory and greenhouse conditions. The results showed that all tested PDE inhibitors reduced tomato root galling significantly compared with the untreated check. Diazepam, papaverine and caffeine treatments gave the highest reduction in root galls by 95.5, 93.3 and 91%, respectively.Diazepam exhibited strong nematicidal activity against second-stage juveniles (J2) of M. incognita with 48hrs-LC50 value of 4.63 ppm. Therefore, using phosphodiesterase inhibitors could serve as the basis for novel nematicides with greater efficacy and reduced environmental impact.
Keywords
Root-knot nematodes; Meloidogyne incognita; Phosphodiesterase (PDE); PDE inhibitors
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