Coasting Versus GnRH Antagonist administration in Patients at High Risk of Ovarian Hyper stimulation Syndrome and its impact on the ICSI Outcome | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 3, Volume 25, Issue 2 - Serial Number 11106352, May 2021, Page 19-27 PDF (2.37 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2021.170462 | ||||
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| Author | ||||
| Eman Anwar Hassan | ||||
| International Islamic Centre for Population Studies and Researches (IICPR) Al-Azhar University, | ||||
| Abstract | ||||
| Objectives: study the value of GnRH antagonist administration as an alternative protocol to coasting in preventing severe OHSS in cases of long agonist ovarian stimulation protocol and its impact on embryos quality &positive pregnancy in women undergoing ICSI. Study design: A prospective randomized control trial is done at the assisted Reproduction unit, Al-Azhar university, Egypt to compare Coasting group (n = 150) and GnRH antagonist group (n = 150) in patients detected to be at risk of OHSS during the process OHSS in cases of long agonist ovarian stimulation protocol before ICSI. The primary outcome was high quality embryos, the secondary outcome was days of intervention, number of oocytes, pregnancy outcome, number of cryopreserved embryos and incidence of severe OHSS. Results: There were statistical significant deference between quality embryos (2.3±1.2 versus 1.6±0.7; P value = 0.001) and more oocytes number (8.2±3.1) versus (6.7±3.2; P value = 0.01) in Antagonist group as compared with coasting group. There were more number of coasting days than with antagonist administration days (2.9±1.4 versus 2.2±1.1; P value = 0.001). Conclusion: GnRH antagonist was superior to coasting in producing higher numbers of mature oocytes, high quality embryos and reducing the number of days till the HCG injection. There was no statistical significant difference in chemical pregnancy rate between two groups. No early or late OHSS developed in either group. | ||||
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