DETECTION OF INSULIN RESISTANCE AND RISK OF TYPE 2 DIABETES MELLITUS AMONG BISPHENOL A EXPOSED WORKERS. | ||||
| Egyptian Journal of Occupational Medicine | ||||
| Article 1, Volume 45, Issue 2, May 2021, Page 1-16 PDF (1.17 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejom.2021.170558 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Mourad BH* | ||||
| Department of Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt. | ||||
| Abstract | ||||
| Introduction: Many previous studies suggested that bisphenol A (BPA) exposure could trigger insulin resistance (IR) and elevate the risk to develop type 2 diabetes mellitus (T2DM). Aim of work: This research was done to detect IR prevalence and risk to develop T2DM among non-diabetic BPA exposed workers involved in the plastic industry. Materials and Methods: This work was conducted in a factory for manufacturing polyvinyl chloride (PVC) pipes present in the 10th of Ramadan City, Egypt. The study population involved an exposed group of 44 non-diabetic workers occupationally-exposed to the plastics manufacturing process and a control group < br />of 46 non-diabetic matching administrative subjects. Full medical and occupational histories in addition to clinical examination, were done. Fasting serum samples were used to measure adiponectin, insulin, lipid profile parameters: Total cholesterol (TC), Triglycerides (TG), Low-density lipoproteins (LDL), and High-density lipoproteins (HDL) and BPA levels. Insulin resistance was evaluated using homeostasis model assessment of insulin resistance (HOMA-IR). Results: The study showed a statistically significant increase in the levels of BPA, insulin, TC, TG and LDL, in addition to HOMA-IR indices, and a statistically significant decrease in the levels of adiponectin and HDL among BPA exposed workers compared to the control group. All measured parameters of IR were significantly correlated with each other, with the BPA levels, and with the duration of occupational exposure among the exposed workers. Conclusion: Long-term occupational exposure to BPA in the plastic industry is accompanied by an elevated risk of developing IR and hence T2DM. | ||||
| Keywords | ||||
| Insulin resistance; Risk of Type 2 Diabetes Mellitus; Adiponectin; Lipid; profile Bisphenol A and Plastic Industry | ||||
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