Effect of Bone Marrow Derived-Mesenchymal Stem Cells on Submandibular Salivary Glands of Carbimazole Induced Hypothyroidism in Albino Rats
el dahrawy, D., Adawy, H., eldeeb, M. (2021). Effect of Bone Marrow Derived-Mesenchymal Stem Cells on Submandibular Salivary Glands of Carbimazole Induced Hypothyroidism in Albino Rats. EKB Journal Management System, 8(2-C), 277-284. doi: 10.21608/adjg.2021.29129.1252
dina el dahrawy; Heba Adawy; mona eldeeb. "Effect of Bone Marrow Derived-Mesenchymal Stem Cells on Submandibular Salivary Glands of Carbimazole Induced Hypothyroidism in Albino Rats". EKB Journal Management System, 8, 2-C, 2021, 277-284. doi: 10.21608/adjg.2021.29129.1252
el dahrawy, D., Adawy, H., eldeeb, M. (2021). 'Effect of Bone Marrow Derived-Mesenchymal Stem Cells on Submandibular Salivary Glands of Carbimazole Induced Hypothyroidism in Albino Rats', EKB Journal Management System, 8(2-C), pp. 277-284. doi: 10.21608/adjg.2021.29129.1252
el dahrawy, D., Adawy, H., eldeeb, M. Effect of Bone Marrow Derived-Mesenchymal Stem Cells on Submandibular Salivary Glands of Carbimazole Induced Hypothyroidism in Albino Rats. EKB Journal Management System, 2021; 8(2-C): 277-284. doi: 10.21608/adjg.2021.29129.1252

Effect of Bone Marrow Derived-Mesenchymal Stem Cells on Submandibular Salivary Glands of Carbimazole Induced Hypothyroidism in Albino Rats

Al-Azhar Dental Journal for Girls
Article 13, Volume 8, 2-C, April 2021, Page 277-284  XML PDF (1.9 MB)
Document Type: Original Article
DOI: 10.21608/adjg.2021.29129.1252
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Authors
dina el dahrawy email 1; Heba Adawy2; mona eldeeb3
1Teaching assistant of Oral Biology, Oral Biology Department, Faculty of Oral and Dental Medicine, Future University in Egypt.
2Professor of Oral Biology, Oral Biology Department, Faculty of Dental Medicine for Girls, Al –Azhar University.
3Professor of Oral Biology, Oral biology Department, Faculty of Oral and Dental Medicine, Future University in Egypt.
Abstract
Purpose: This study was aimed to estimate the effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on the submandibular salivary gland of induced hypothyroidism in rats. Material and Methods: Thirty adult male albino rats weighing between 200-250 grams were used in the present study. The animals were divided into three equal groups: Group I (control group), Group II (carbimazole induced hypothyroidism group): Rats received a daily dose of carbimazole (5mg/250g/day) for 5 weeks, Group III (BM-MSCs treated group): Hypothyroidism was induced similar to group II, then rats were injected with 1x 107 BM-MSCs cells. All Rats were euthanized after 8 weeks (5 weeks of hypothyroidism induction + 3 weeks of stem cells injection). Results: group (II) showed excessive destruction and degenerative changes of the acini and ducts in comparison to group (I), while group (III) revealed marked improvement of the parenchymal elements after BM-MSCs injection. Conclusions: This study supposes that BM-MSCs improve salivary glands damage following induction of hypothyroidism. Therefore, BM-MSCs can be applied as cell-based therapy for restoration of hypothyroid-induced salivary hypofunction.
Keywords
Bone marrow derived mesenchymal stem cells; submandibular salivary gland; carbimazole; hypothyroidism
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