Maternal Serum C-Reactive Protein for Prediction of Maternal and Perinatal Morbidity in Premature Rupture of Membranes
Shaaban, A., Fathey, A., Abdelgied, A., Dawood, R., Dawoud, M. (2021). Maternal Serum C-Reactive Protein for Prediction of Maternal and Perinatal Morbidity in Premature Rupture of Membranes. EKB Journal Management System, 83(1), 1554-1552. doi: 10.21608/ejhm.2021.171401
Ahmed Tawfiek Shaaban; Amira Ahmed Fathey; Alaa Masoud Abdelgied; Ragab Mohamed Dawood; Marwa Mohammed Dawoud. "Maternal Serum C-Reactive Protein for Prediction of Maternal and Perinatal Morbidity in Premature Rupture of Membranes". EKB Journal Management System, 83, 1, 2021, 1554-1552. doi: 10.21608/ejhm.2021.171401
Shaaban, A., Fathey, A., Abdelgied, A., Dawood, R., Dawoud, M. (2021). 'Maternal Serum C-Reactive Protein for Prediction of Maternal and Perinatal Morbidity in Premature Rupture of Membranes', EKB Journal Management System, 83(1), pp. 1554-1552. doi: 10.21608/ejhm.2021.171401
Shaaban, A., Fathey, A., Abdelgied, A., Dawood, R., Dawoud, M. Maternal Serum C-Reactive Protein for Prediction of Maternal and Perinatal Morbidity in Premature Rupture of Membranes. EKB Journal Management System, 2021; 83(1): 1554-1552. doi: 10.21608/ejhm.2021.171401

Maternal Serum C-Reactive Protein for Prediction of Maternal and Perinatal Morbidity in Premature Rupture of Membranes

The Egyptian Journal of Hospital Medicine
Article 113, Volume 83, Issue 1, April 2021, Page 1554-1552  XML PDF (698.39 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.171401
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Authors
Ahmed Tawfiek Shaaban email 1; Amira Ahmed Fathey1; Alaa Masoud Abdelgied1; Ragab Mohamed Dawood1; Marwa Mohammed Dawoud2
1Departments of 1Obstetrics and Gynecology Menoufia University, Menoufia, Egypt
2Departments of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Abstract
Background: Premature rupture of membranes (PROM) is defined as spontaneous rupture of membranes before the onset of uterine contraction. If the rupture of the membranes occurs after 28 weeks but before 37 weeks of gestation it is termed as PPROM (Preterm Premature Rupture of Membranes).
Objective: To assess the role of the C- reactive protein (CRP) as a reliable predictor of chorioamnionitis in premature rupture of membranes (PROM).
Patients and methods: This is an observational prospective study that was conducted on 120 pregnant women admitted to Menoufia University Hospitals and Shebin EL-Kom Teaching Hospital during the period from October 2019 till December 2020.
Results: CRP level has sensitivity and specificity of (87.5% and 88.7%) respectively, at cutoff value >13 with area under curve of 0.915 with accuracy of 76.3% as the diagnostic tool in PPROM cases with histological chorioamnionitis (HCA). Also, C-reactive protein was significantly positively correlated with placental examination HCA, offensive discharge, ESR at 2nd hour, and TLC (p < 0.05). Also, C-reactive protein was significantly negatively correlated with amniotic fluid index (AFI), Apgar score at (5, 10 minutes) and fetal weight at delivery (p < 0.05). While, there was insignificant correlation between CRP with ESR at 1st hour among the studied patients (P>0.05).
Conclusion: CRP has a role for detection of maternal and perinatal morbidity with accuracy about 76% and can be used as an early predictor for morbidity in pregnant women with PPROM. Pregnant women with PPROM who had CRP level ≤13 mg/l should have expectant management if there are no other contraindications and those have CRP level >13 mg/l; termination of pregnancy should be taken in consideration in presence of signs of clinical chorioamnionitis.
 
Keywords
C-reactive protein; Perinatal; Premature; PROM; rupture of membranes
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